The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses
- PMID: 3019203
- DOI: 10.7326/0003-4819-105-4-560
The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses
Abstract
The human receptor for interleukin-2 (T-cell growth factor) plays a critical role in the growth of T cells and is required for full expression of the normal immune response. Through hybridoma and recombinant DNA techniques, the interleukin-2 receptor protein has been biochemically characterized and purified; full-length copies of its complementary DNA have been molecularly cloned, sequenced, and expressed in eukaryotic cells; and the receptor gene has been characterized. Transient expression of the interleukin-2 receptor gene occurs during normal T-cell activation, and high- and low-affinity forms of the membrane receptor exist. A naturally occurring, soluble receptor has also been isolated, and its levels in serum correlate with the activity of various diseases. Deregulation of interleukin-2 receptor expression occurs in T-cell leukemias produced by the human T-lymphotropic retroviruses types I and II (HTLV-I and -II) and has been causally linked to the action of the trans-activator (taf) gene of these viruses. Monoclonal antibodies specific for the interleukin-2 receptor are being evaluated in the treatment of HTLV-I-induced leukemias and other conditions involving the inappropriate function of activated T cells.
Similar articles
-
Interleukin 2 receptor (Tac antigen) expression in HTLV-I-associated adult T-cell leukemia.Cancer Res. 1985 Sep;45(9 Suppl):4559s-4562s. Cancer Res. 1985. PMID: 2990687
-
Interleukin-2 receptor expression in retrovirus associated adult T-cell leukemia.Princess Takamatsu Symp. 1984;15:259-68. Princess Takamatsu Symp. 1984. PMID: 6100644
-
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.Science. 1986 May 16;232(4752):877-80. doi: 10.1126/science.3010456. Science. 1986. PMID: 3010456
-
Immunopathology associated with human lymphotropic retroviruses.Surv Synth Pathol Res. 1985;4(3):216-26. doi: 10.1159/000156975. Surv Synth Pathol Res. 1985. PMID: 2421386 Review.
-
The human interleukin-2 receptor.Annu Rev Immunol. 1986;4:69-95. doi: 10.1146/annurev.iy.04.040186.000441. Annu Rev Immunol. 1986. PMID: 3011033 Review. No abstract available.
Cited by
-
A soluble, high-affinity, interleukin-4-binding protein is present in the biological fluids of mice.Proc Natl Acad Sci U S A. 1990 Jun;87(11):4202-6. doi: 10.1073/pnas.87.11.4202. Proc Natl Acad Sci U S A. 1990. PMID: 2349230 Free PMC article.
-
Serum levels of soluble interleukin-2 receptors and effects of interferon-alpha for patients with chronic hepatitis C virus.Dig Dis Sci. 1995 Aug;40(8):1837-41. doi: 10.1007/BF02212710. Dig Dis Sci. 1995. PMID: 7648988
-
Familial hemophagocytic lymphohistiocytosis associated with disseminated T-cell lymphoma: a report of two siblings.Ann Hematol. 1994 Aug;69(2):85-91. doi: 10.1007/BF01698488. Ann Hematol. 1994. PMID: 8080885
-
Constitutive secretion of soluble interleukin-2 receptor by human T cell lymphoma xenografted into SCID mice. Correlation of tumor volume with concentration of tumor-derived soluble interleukin-2 receptor in body fluids of the host mice.Am J Pathol. 1994 May;144(5):1089-97. Am J Pathol. 1994. PMID: 8178932 Free PMC article.
-
Retroviruses and malignant lymphoma.Blut. 1989 May;58(5):221-7. doi: 10.1007/BF00320909. Blut. 1989. PMID: 2541838 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
