Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

doi:10.1038/s41556-018-0176-2

Review

. 2018 Sep;20(9):1013-1022.

doi: 10.1038/s41556-018-0176-2. Epub 2018 Aug 28.

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras^{1

2}, Eirini Lionaki¹, Nektarios Tavernarakis^{3

4}

Affiliations

¹ Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
² Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
³ Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece. tavernarakis@imbb.forth.gr.
⁴ Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece. tavernarakis@imbb.forth.gr.

PMID: 30154567
DOI: 10.1038/s41556-018-0176-2

Review

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al. Nat Cell Biol. 2018 Sep.

. 2018 Sep;20(9):1013-1022.

doi: 10.1038/s41556-018-0176-2. Epub 2018 Aug 28.

Authors

Konstantinos Palikaras^{1

2}, Eirini Lionaki¹, Nektarios Tavernarakis^{3

4}

Affiliations

¹ Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
² Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece.
³ Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece. tavernarakis@imbb.forth.gr.
⁴ Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece. tavernarakis@imbb.forth.gr.

PMID: 30154567
DOI: 10.1038/s41556-018-0176-2

Abstract

Mitophagy is an evolutionarily conserved cellular process to remove dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial number and preserving energy metabolism. In this Review, we survey recent advances towards elucidating the molecular mechanisms that mediate mitochondrial elimination and the signalling pathways that govern mitophagy. We consider the contributions of mitophagy in physiological and pathological contexts and discuss emerging findings, highlighting the potential value of mitophagy modulation in therapeutic intervention.

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References

1. Palikaras, K., Daskalaki, I., Markaki, M. & Tavernarakis, N. Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover. Pharmacol. Ther. 178, 157–174 (2017). - PubMed - DOI
1. Ashrafi, G. & Schwarz, T. L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20, 31–42 (2013). - PubMed - DOI
1. Khaminets, A., Behl, C. & Dikic, I. Ubiquitin-dependent And independent signals in selective autophagy. Trends Cell Biol. 26, 6–16 (2016). - PubMed - DOI
1. Pickles, S., Vigie, P. & Youle, R. J. Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr. Biol. 28, R170–R185 (2018). - PubMed - DOI
1. Harper, J. W., Ordureau, A. & Heo, J. M. Building and decoding ubiquitin chains for mitophagy. Nat. Rev. Mol. Cell Biol. 19, 93–108 (2018). - PubMed - DOI

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[1] Palikaras, K., Daskalaki, I., Markaki, M. & Tavernarakis, N. Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover. Pharmacol. Ther. 178, 157–174 (2017). - PubMed - DOI

[2] Palikaras, K., Daskalaki, I., Markaki, M. & Tavernarakis, N. Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover. Pharmacol. Ther. 178, 157–174 (2017). - PubMed - DOI

[3] Ashrafi, G. & Schwarz, T. L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20, 31–42 (2013). - PubMed - DOI

[4] Ashrafi, G. & Schwarz, T. L. The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20, 31–42 (2013). - PubMed - DOI

[5] Khaminets, A., Behl, C. & Dikic, I. Ubiquitin-dependent And independent signals in selective autophagy. Trends Cell Biol. 26, 6–16 (2016). - PubMed - DOI

[6] Khaminets, A., Behl, C. & Dikic, I. Ubiquitin-dependent And independent signals in selective autophagy. Trends Cell Biol. 26, 6–16 (2016). - PubMed - DOI

[7] Pickles, S., Vigie, P. & Youle, R. J. Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr. Biol. 28, R170–R185 (2018). - PubMed - DOI

[8] Pickles, S., Vigie, P. & Youle, R. J. Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr. Biol. 28, R170–R185 (2018). - PubMed - DOI

[9] Harper, J. W., Ordureau, A. & Heo, J. M. Building and decoding ubiquitin chains for mitophagy. Nat. Rev. Mol. Cell Biol. 19, 93–108 (2018). - PubMed - DOI

[10] Harper, J. W., Ordureau, A. & Heo, J. M. Building and decoding ubiquitin chains for mitophagy. Nat. Rev. Mol. Cell Biol. 19, 93–108 (2018). - PubMed - DOI

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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

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Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

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