Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

doi:10.1016/j.matbio.2018.08.007

Review

. 2019 Jan:75-76:1-11.

doi: 10.1016/j.matbio.2018.08.007. Epub 2018 Aug 18.

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

Nikos K Karamanos¹, Achilleas D Theocharis², Thomas Neill³, Renato V Iozzo³

Affiliations

¹ Biochemistry, Biochemical Analysis and Matrix Pathobiochemistry Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece. Electronic address: n.k.karamanos@upatras.gr.
² Biochemistry, Biochemical Analysis and Matrix Pathobiochemistry Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.
³ Department of Pathology, Anatomy, and Cell Biology, Cancer Cell Biology and Signaling Program, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.

PMID: 30130584
PMCID: PMC6377817
DOI: 10.1016/j.matbio.2018.08.007

Review

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

Nikos K Karamanos et al. Matrix Biol. 2019 Jan.

. 2019 Jan:75-76:1-11.

doi: 10.1016/j.matbio.2018.08.007. Epub 2018 Aug 18.

Authors

Nikos K Karamanos¹, Achilleas D Theocharis², Thomas Neill³, Renato V Iozzo³

Affiliations

¹ Biochemistry, Biochemical Analysis and Matrix Pathobiochemistry Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece. Electronic address: n.k.karamanos@upatras.gr.
² Biochemistry, Biochemical Analysis and Matrix Pathobiochemistry Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.
³ Department of Pathology, Anatomy, and Cell Biology, Cancer Cell Biology and Signaling Program, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA 19107, USA.

PMID: 30130584
PMCID: PMC6377817
DOI: 10.1016/j.matbio.2018.08.007

Abstract

The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.

Keywords: Cancer; Collagens; Proteases; Proteoglycans; Senescence.

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Conflict of interest statement

Conflicts of interest

The author declares no conflict of interest.

Figures

**Fig. 1.**
Schematic depiction of matrix modeling and remodeling driven by SASP and various proteolytic effectors including MMPs and cathepsins. Please consult the text for additional information.

**Fig. 2.**
Schematic representation of various roles discovered for proteoglycans in regulating development, as biomarkers in adverse cardiac events, and in controlling tumorigenesis and catabolism. Please refer to the text for additional information.

See this image and copyright information in PMC

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References

1. Iozzo RV, Moscatello D, McQuillan DJ, Eichstetter I, Decorin is a biological ligand for the epidermal growth factor receptor, J. Biol. Chem. 274 (1999) 4489–4492. - PubMed
1. Goldoni S, Humphries A, Nyström A, Sattar S, Owens RT, McQuillan DJ et al., Decorin is a novel antagonistic ligand of the Met receptor, J. Cell Biol. 185 (2009) 743–754. - PMC - PubMed
1. Goldoni S, Owens RT, McQuillan DJ, Shriver Z, Sasisekharan R, Birk DE et al., Biologically active decorin is a monomer in solution, J. Biol. Chem. 279 (2004) 6606–6612. - PubMed
1. Ferdous Z, Wei VM, Iozzo RV, Höök M, Grande-Allen KJ, Decorin-transforming growth factor-β interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices, J. Biol. Chem. 282 (2007) 35887–35898. - PubMed
1. Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB, Latent TGF-β-binding proteins, Matrix Biol. 47 (2015) 44–53. - PMC - PubMed

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[1] Iozzo RV, Moscatello D, McQuillan DJ, Eichstetter I, Decorin is a biological ligand for the epidermal growth factor receptor, J. Biol. Chem. 274 (1999) 4489–4492. - PubMed

[2] Iozzo RV, Moscatello D, McQuillan DJ, Eichstetter I, Decorin is a biological ligand for the epidermal growth factor receptor, J. Biol. Chem. 274 (1999) 4489–4492. - PubMed

[3] Goldoni S, Humphries A, Nyström A, Sattar S, Owens RT, McQuillan DJ et al., Decorin is a novel antagonistic ligand of the Met receptor, J. Cell Biol. 185 (2009) 743–754. - PMC - PubMed

[4] Goldoni S, Humphries A, Nyström A, Sattar S, Owens RT, McQuillan DJ et al., Decorin is a novel antagonistic ligand of the Met receptor, J. Cell Biol. 185 (2009) 743–754. - PMC - PubMed

[5] Goldoni S, Owens RT, McQuillan DJ, Shriver Z, Sasisekharan R, Birk DE et al., Biologically active decorin is a monomer in solution, J. Biol. Chem. 279 (2004) 6606–6612. - PubMed

[6] Goldoni S, Owens RT, McQuillan DJ, Shriver Z, Sasisekharan R, Birk DE et al., Biologically active decorin is a monomer in solution, J. Biol. Chem. 279 (2004) 6606–6612. - PubMed

[7] Ferdous Z, Wei VM, Iozzo RV, Höök M, Grande-Allen KJ, Decorin-transforming growth factor-β interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices, J. Biol. Chem. 282 (2007) 35887–35898. - PubMed

[8] Ferdous Z, Wei VM, Iozzo RV, Höök M, Grande-Allen KJ, Decorin-transforming growth factor-β interaction regulates matrix organization and mechanical characteristics of three-dimensional collagen matrices, J. Biol. Chem. 282 (2007) 35887–35898. - PubMed

[9] Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB, Latent TGF-β-binding proteins, Matrix Biol. 47 (2015) 44–53. - PMC - PubMed

[10] Robertson IB, Horiguchi M, Zilberberg L, Dabovic B, Hadjiolova K, Rifkin DB, Latent TGF-β-binding proteins, Matrix Biol. 47 (2015) 44–53. - PMC - PubMed

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Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

Affiliations

Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases

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Conflict of interest statement

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