New approaches and challenges to targeting the endocannabinoid system

doi:10.1038/nrd.2018.115

Review

. 2018 Sep;17(9):623-639.

doi: 10.1038/nrd.2018.115. Epub 2018 Aug 17.

New approaches and challenges to targeting the endocannabinoid system

Vincenzo Di Marzo^{1

2}

Affiliations

¹ Canada Excellence Research Chair, Quebec Heart and Lung Institute Research Centre and Institute of Nutrition and Functional Foods, Université Laval, Quebec City, Quebec, Canada.
² Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy.

PMID: 30116049
DOI: 10.1038/nrd.2018.115

Review

New approaches and challenges to targeting the endocannabinoid system

Vincenzo Di Marzo. Nat Rev Drug Discov. 2018 Sep.

. 2018 Sep;17(9):623-639.

doi: 10.1038/nrd.2018.115. Epub 2018 Aug 17.

Author

Vincenzo Di Marzo^{1

2}

Affiliations

¹ Canada Excellence Research Chair, Quebec Heart and Lung Institute Research Centre and Institute of Nutrition and Functional Foods, Université Laval, Quebec City, Quebec, Canada.
² Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy.

PMID: 30116049
DOI: 10.1038/nrd.2018.115

Erratum in

Corrigendum: New approaches and challenges to targeting the endocannabinoid system.
Marzo VD. Marzo VD. Nat Rev Drug Discov. 2018 Aug 30;17(9):688. doi: 10.1038/nrd.2018.155. Nat Rev Drug Discov. 2018. PMID: 30160249

Abstract

The endocannabinoid signalling system was discovered because receptors in this system are the targets of compounds present in psychotropic preparations of Cannabis sativa. The search for new therapeutics that target endocannabinoid signalling is both challenging and potentially rewarding, as endocannabinoids are implicated in numerous physiological and pathological processes. Hundreds of mediators chemically related to the endocannabinoids, often with similar metabolic pathways but different targets, have complicated the development of inhibitors of endocannabinoid metabolic enzymes but have also stimulated the rational design of multi-target drugs. Meanwhile, drugs based on botanical cannabinoids have come to the clinical forefront, synthetic agonists designed to bind cannabinoid receptor 1 with very high affinity have become a societal threat and the gut microbiome has been found to signal in part through the endocannabinoid network. The current development of drugs that alter endocannabinoid signalling and how this complex system could be pharmacologically manipulated in the future are described in this Opinion article.

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[1] Sci Rep. 2017 Nov 15;7(1):15645 - PubMed

[2] Sci Rep. 2017 Nov 15;7(1):15645 - PubMed

[3] Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2472-81 - PubMed

[4] Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):E2472-81 - PubMed

[5] PLoS One. 2010 Apr 22;5(4):e10239 - PubMed

[6] PLoS One. 2010 Apr 22;5(4):e10239 - PubMed

[7] Front Neurosci. 2016 Sep 13;10:406 - PubMed

[8] Front Neurosci. 2016 Sep 13;10:406 - PubMed

[9] J Biol Chem. 2017 May 26;292(21):8553-8559 - PubMed

[10] J Biol Chem. 2017 May 26;292(21):8553-8559 - PubMed

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New approaches and challenges to targeting the endocannabinoid system

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New approaches and challenges to targeting the endocannabinoid system

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