Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Sep:74:144-146.
doi: 10.1016/j.ceca.2018.07.006. Epub 2018 Jul 19.

Revelation of an enigmatic signaling machinery-First insights into the mammalian TRPC architecture

Klaus Groschner  1 , Oleksandra Tiapko  2
Affiliations
Review

Revelation of an enigmatic signaling machinery-First insights into the mammalian TRPC architecture

Klaus Groschner et al. Cell Calcium. 2018 Sep.

Abstract

Canonical TRP channels (TRPCs) are a particularly enigmatic family of signaling molecules with multimodal sensing features, being involved in a wide range of biological functions. Until very recently, the main hurdle towards comprehensive mechanistic understanding of TRPC signaling has been the lack of structural information. This has changed early this year by several reports on TRPC architectures resolved by single particle cryo-EM analysis. These studies confirmed recently elaborated concepts on TRPC structure-function relations, and unveiled unanticipated features and complexity in the TRPC sensing machinery.

Keywords: Cryo-EM; Gating machinery; Molecular architecture; TRPC channels.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types

Substances

LinkOut - more resources