[Myeloperoxidase deficiency as a cause of recurrent infections]
- PMID: 2999502
- DOI: 10.1055/s-2008-1034019
[Myeloperoxidase deficiency as a cause of recurrent infections]
Abstract
Myeloperoxidase (MPO) deficiency is a common hereditary leukocyte function defect. A two year old girl with MPO-deficiency suffered from recurrent skin infections. No MPO-activity was detectable in leukocytes of her peripheral blood smears, while NBT reduction and chemotactic activity was normal. The quantitative enzyme determination in leukocyte sonicates confirmed the total MPO-deficiency in the girl's leukocytes and a partial MPO-deficiency in the cells of her mother. The patient leukocytes demonstrated also an impaired chemiluminescence.
Similar articles
-
Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection.J Clin Invest. 1969 Aug;48(8):1478-88. doi: 10.1172/JCI106114. J Clin Invest. 1969. PMID: 5796360 Free PMC article.
-
Does a relationship exist between neutrophil myeloperoxidase deficiency and the occurrence of neoplasms?J Clin Lab Immunol. 1987 Apr;22(4):175-80. J Clin Lab Immunol. 1987. PMID: 3039142
-
[Myeloperoxidase deficiency--blemish or disease? Evaluation of 60,337 differential blood pictures].Schweiz Med Wochenschr. 1986 Oct 25;116(43):1487-8. Schweiz Med Wochenschr. 1986. PMID: 3024310 German.
-
Leukocyte functions.Lab Invest. 1987 Feb;56(2):127-37. Lab Invest. 1987. PMID: 3543488 Review.
-
Myeloperoxidase deficiency.Hematol Oncol Clin North Am. 1988 Mar;2(1):135-58. Hematol Oncol Clin North Am. 1988. PMID: 2831185 Review.
Cited by
-
Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples.J Vis Exp. 2016 Jul 28;(113):54484. doi: 10.3791/54484. J Vis Exp. 2016. PMID: 27501318 Free PMC article.
-
Myeloperoxidase: a front-line defender against phagocytosed microorganisms.J Leukoc Biol. 2013 Feb;93(2):185-98. doi: 10.1189/jlb.0712349. Epub 2012 Oct 11. J Leukoc Biol. 2013. PMID: 23066164 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous