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Comparative Study
. 1985 Sep;55(3):836-9.
doi: 10.1128/JVI.55.3.836-839.1985.

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide

E A Emini, J V Hughes, D S Perlow, J Boger
Comparative Study

Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide

E A Emini et al. J Virol. 1985 Sep.

Abstract

Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.

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