Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

doi:10.3390/cells7060062

Review

. 2018 Jun 15;7(6):62.

doi: 10.3390/cells7060062.

Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

Chen Wang¹, Keiji Naruse², Ken Takahashi³

Affiliations

¹ Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. wangchen11228@gmail.com.
² Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. knaruse@md.okayama-u.ac.jp.
³ Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. takah-k2@okayama-u.ac.jp.

PMID: 29914130
PMCID: PMC6025450
DOI: 10.3390/cells7060062

Review

Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

Chen Wang et al. Cells. 2018.

. 2018 Jun 15;7(6):62.

doi: 10.3390/cells7060062.

Authors

Chen Wang¹, Keiji Naruse², Ken Takahashi³

Affiliations

¹ Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. wangchen11228@gmail.com.
² Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. knaruse@md.okayama-u.ac.jp.
³ Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. takah-k2@okayama-u.ac.jp.

PMID: 29914130
PMCID: PMC6025450
DOI: 10.3390/cells7060062

Abstract

The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology.

Keywords: TRPM4 channel; cardiovascular system; pathophysiology; physiology.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Guinamard R., Demion M., Launay P. Physiological roles of the trpm4 channel extracted from background currents. Physiology. 2010;25:155–164. doi: 10.1152/physiol.00004.2010. - DOI - PubMed
1. Launay P., Fleig A., Perraud A.L., Scharenberg A.M., Penner R., Kinet J.P. Trpm4 is a ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002;109:397–407. doi: 10.1016/S0092-8674(02)00719-5. - DOI - PubMed
1. Song M.Y., Yuan J.X. Introduction to trp channels: Structure, function, and regulation. Adv. Exp. Med. Biol. 2010;661:99–108. - PubMed
1. Fleig A., Penner R. The trpm ion channel subfamily: Molecular, biophysical and functional features. Trends Pharmacol. Sci. 2004;25:633–639. doi: 10.1016/j.tips.2004.10.004. - DOI - PubMed
1. Mathar I., Jacobs G., Kecskes M., Menigoz A., Philippaert K., Vennekens R. Trpm4. Handb. Exp. Pharmacol. 2014;222:461–487. - PubMed

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[1] Guinamard R., Demion M., Launay P. Physiological roles of the trpm4 channel extracted from background currents. Physiology. 2010;25:155–164. doi: 10.1152/physiol.00004.2010. - DOI - PubMed

[2] Guinamard R., Demion M., Launay P. Physiological roles of the trpm4 channel extracted from background currents. Physiology. 2010;25:155–164. doi: 10.1152/physiol.00004.2010. - DOI - PubMed

[3] Launay P., Fleig A., Perraud A.L., Scharenberg A.M., Penner R., Kinet J.P. Trpm4 is a ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002;109:397–407. doi: 10.1016/S0092-8674(02)00719-5. - DOI - PubMed

[4] Launay P., Fleig A., Perraud A.L., Scharenberg A.M., Penner R., Kinet J.P. Trpm4 is a ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002;109:397–407. doi: 10.1016/S0092-8674(02)00719-5. - DOI - PubMed

[5] Song M.Y., Yuan J.X. Introduction to trp channels: Structure, function, and regulation. Adv. Exp. Med. Biol. 2010;661:99–108. - PubMed

[6] Song M.Y., Yuan J.X. Introduction to trp channels: Structure, function, and regulation. Adv. Exp. Med. Biol. 2010;661:99–108. - PubMed

[7] Fleig A., Penner R. The trpm ion channel subfamily: Molecular, biophysical and functional features. Trends Pharmacol. Sci. 2004;25:633–639. doi: 10.1016/j.tips.2004.10.004. - DOI - PubMed

[8] Fleig A., Penner R. The trpm ion channel subfamily: Molecular, biophysical and functional features. Trends Pharmacol. Sci. 2004;25:633–639. doi: 10.1016/j.tips.2004.10.004. - DOI - PubMed

[9] Mathar I., Jacobs G., Kecskes M., Menigoz A., Philippaert K., Vennekens R. Trpm4. Handb. Exp. Pharmacol. 2014;222:461–487. - PubMed

[10] Mathar I., Jacobs G., Kecskes M., Menigoz A., Philippaert K., Vennekens R. Trpm4. Handb. Exp. Pharmacol. 2014;222:461–487. - PubMed

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Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

Affiliations

Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

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