Trans-activator gene of human T-lymphotropic virus type III (HTLV-III)
- PMID: 2990040
- DOI: 10.1126/science.2990040
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III)
Abstract
Human T-lymphotropic virus type III (HTLV-III) encodes a trans-acting factor that activates the expression of genes linked to the HTLV-III long terminal repeat. By functional mapping of complementary DNA transcripts of viral messenger RNA's the major functional domain of the gene encoding this factor was localized to a region immediately before the env gene of the virus, a region previously thought to be noncoding. This newly identified gene consists of three exons, and its transcription into messenger RNA involves two splicing events bringing together sequences from the 5' part (287 base pairs), middle (268 base pairs), and 3'part (1258 base pairs) of the HTLV-III genome. A similar messenger RNA with a truncated second exon (70 base pairs) does not encode a trans-acting function. It is proposed that this second messenger RNA is the transcript of a gene (3'-orf) located after the env gene. Messenger RNA's were also identified for the env and gag-pol genes of HTLV-III.
Similar articles
-
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.Science. 1985 Jul 5;229(4708):74-7. doi: 10.1126/science.2990041. Science. 1985. PMID: 2990041
-
The trans-activator gene of HTLV-III is essential for virus replication.Nature. 1986 Mar 27-Apr 2;320(6060):367-71. doi: 10.1038/320367a0. Nature. 1986. PMID: 3007995
-
Molecular biology of human T-lymphotropic retroviruses.Cancer Res. 1985 Sep;45(9 Suppl):4539s-4544s. Cancer Res. 1985. PMID: 2990683 Review.
-
Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III.Nature. 1986 Feb 13-19;319(6054):555-9. doi: 10.1038/319555a0. Nature. 1986. PMID: 3003584
-
Structural and antigenic characterization of the proteins of human T-cell leukemia viruses and their relationships to the gene products of other retroviruses.Princess Takamatsu Symp. 1984;15:147-57. Princess Takamatsu Symp. 1984. PMID: 6100635 Review.
Cited by
-
Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.Proc Natl Acad Sci U S A. 1989 Jul;86(13):4858-62. doi: 10.1073/pnas.86.13.4858. Proc Natl Acad Sci U S A. 1989. PMID: 2544877 Free PMC article.
-
Functional significance of phosphorylation to the human immunodeficiency virus Rev protein.J Virol. 1989 Oct;63(10):4438-40. doi: 10.1128/JVI.63.10.4438-4440.1989. J Virol. 1989. PMID: 2550674 Free PMC article.
-
Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription.J Virol. 1992 Jun;66(6):3883-7. doi: 10.1128/JVI.66.6.3883-3887.1992. J Virol. 1992. PMID: 1583734 Free PMC article.
-
Purification of the human immunodeficiency virus type 1 enhancer and TAR binding proteins EBP-1 and UBP-1.EMBO J. 1988 Jul;7(7):2117-30. doi: 10.1002/j.1460-2075.1988.tb03051.x. EMBO J. 1988. PMID: 3138113 Free PMC article.
-
Antibodies to recombinant HIV-1 vif, tat, and nef proteins in human sera.Med Microbiol Immunol. 1990;179(1):1-11. doi: 10.1007/BF00190145. Med Microbiol Immunol. 1990. PMID: 2184337
MeSH terms
Substances
Associated data
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
