Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 May;4(5):1279-86.
doi: 10.1002/j.1460-2075.1985.tb03773.x.

A new member of the polyomavirus family: the hamster papovavirus. Complete nucleotide sequence and transformation properties

V Delmas, C Bastien, S Scherneck, J Feunteun

A new member of the polyomavirus family: the hamster papovavirus. Complete nucleotide sequence and transformation properties

V Delmas et al. EMBO J. 1985 May.

Abstract

The hamster papovavirus (HapV) is associated with multiple skin epitheliomas of the Syrian hamster. We have sequenced its genome. It is a double-stranded circular DNA of 5366 bp. The hypothetical genomic organization deduced from this nucleotide sequence is clearly of the polyoma type with the two strands coding in the opposite directions from a noncoding region that shows some of the features of a replication origin and a transcription control region. The amino acid sequences predicted from the open reading frames show an average of 50% homology with polyoma-coded polypeptides. The HapV is, after polyoma, the second example of a papovavirus coding for a middle T antigen. The cloned DNA can immortalize primary rat embryo cells and transform an established rat cell line. The viral DNA is stably integrated into the host genome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Natl Cancer Inst. 1968 Apr;40(4):867-73 - PubMed
    1. Mol Cell Biol. 1984 Jul;4(7):1334-42 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Cell. 1978 Jul;14(3):725-31 - PubMed

Publication types

Associated data