doi: 10.1016/0014-2999(85)90431-5.
[3H]U-69593 a highly selective ligand for the opioid kappa receptor
- PMID: 2986999
- DOI: 10.1016/0014-2999(85)90431-5
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[3H]U-69593 a highly selective ligand for the opioid kappa receptor
Eur J Pharmacol.
.
Abstract
The selective kappa agonist U-50488 was recently discovered and characterized. In this study, the receptor binding properties of [3H]U-69593, an analog of U-50488, were characterized. [3H]U-69593 binds with high affinity (3 nM) to membranes prepared from guinea pig, mouse and rat brain. The number of kappa binding sites comprise only 13%, 9% and 4% of the total opioid sites, respectively. The benzmorphans, dynorphin, and compounds structurally related to U-50488 have high affinity for this kappa site.
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