doi: 10.1016/0006-291x(85)90131-7.
MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF
- PMID: 2986629
- DOI: 10.1016/0006-291x(85)90131-7
Item in Clipboard
MDA-468, a human breast cancer cell line with a high number of epidermal growth factor (EGF) receptors, has an amplified EGF receptor gene and is growth inhibited by EGF
Biochem Biophys Res Commun.
.
Abstract
Epidermal growth factor (EGF) has been noted to stimulate proliferation of a variety of normal and malignant cells including those of human breast epithelium. We report here that MDA-468, a human breast cancer cell line with a very high number of EGF receptors, is growth-inhibited at EGF concentrations that stimulate most other cells. The basis for the elevated receptor level is EGF receptor gene amplification and over-expression. An MDA-468 clone selected for resistance to EGF-induced growth inhibition shows a number of receptors within the normal range. The results are discussed in relation to a threshold model for EGF-induced growth inhibition.
Similar articles
-
Epidermal growth factor receptor gene-amplified MDA-468 breast cancer cell line and its nonamplified variants.Mol Cell Biol. 1987 Jan;7(1):251-7. doi: 10.1128/mcb.7.1.251-257.1987. Mol Cell Biol. 1987. PMID: 3494191 Free PMC article.
-
Amplified, overexpressed and rearranged epidermal growth factor receptor gene in a human astrocytoma cell line.Biochem Biophys Res Commun. 1985 Aug 30;131(1):207-15. doi: 10.1016/0006-291x(85)91790-5. Biochem Biophys Res Commun. 1985. PMID: 2994648
-
Characterization of epidermal growth factor receptor and action on human breast cancer cells in culture.Cancer Res. 1984 Aug;44(8):3442-7. Cancer Res. 1984. PMID: 6331647
-
Relationship between production of epidermal growth factor receptors, gene amplification, and chromosome 7 translocation in variant A431 cells.Somat Cell Mol Genet. 1985 Jul;11(4):309-18. doi: 10.1007/BF01534689. Somat Cell Mol Genet. 1985. PMID: 2410984
-
Regulation of cell proliferation by epidermal growth factor.CRC Crit Rev Biochem. 1983;14(2):93-111. doi: 10.3109/10409238309102791. CRC Crit Rev Biochem. 1983. PMID: 6301752 Review.
Cited by
-
Femtosecond Plasmonic Laser Nanosurgery (fs-PLN) mediated by molecularly targeted gold nanospheres at ultra-low pulse fluences.Sci Rep. 2020 Jul 24;10(1):12387. doi: 10.1038/s41598-020-68512-2. Sci Rep. 2020. PMID: 32709944 Free PMC article.
-
Calmodulin modulates Akt activity in human breast cancer cell lines.Breast Cancer Res Treat. 2009 Jun;115(3):545-60. doi: 10.1007/s10549-008-0097-z. Epub 2008 Jun 28. Breast Cancer Res Treat. 2009. PMID: 18587642 Free PMC article.
-
High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways.PLoS One. 2011 Jan 10;6(1):e15945. doi: 10.1371/journal.pone.0015945. PLoS One. 2011. PMID: 21264347 Free PMC article.
-
Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment.BMC Cancer. 2015 Mar 8;15:109. doi: 10.1186/s12885-015-1131-2. BMC Cancer. 2015. PMID: 25885600 Free PMC article.
-
Activation of the Na+/H+ antiport is not required for epidermal growth factor-dependent gene expression, growth inhibition or proliferation in human breast cancer cells.Biochem J. 1989 Jan 1;257(1):151-7. doi: 10.1042/bj2570151. Biochem J. 1989. PMID: 2537620 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
