In vivo effects of cyclosporine on influenza A virus-infected mice
- PMID: 2982505
- DOI: 10.1016/0008-8749(85)90046-2
In vivo effects of cyclosporine on influenza A virus-infected mice
Abstract
Cyclosporine (cyclosporin A, CsA) administered to mice substantially affects their immune response to an influenza A virus infection. If treated with CsA for 21 days, the mouse lungs contain high titers of virus which are cleared more slowly than in controls. Indicators of pathological damage--lung weight, extent of consolidation, fine morphology, and the extent of infiltration of dividing cells into the lung--showed that administration of CsA greatly decreased the level of inflammation. The production of hemagglutination-inhibiting (HI) antibody was delayed but reached almost control levels and NK cell activity in the lung was also comparable to control levels. In contrast, a delayed-type hypersensitivity (DTH) response to the virus could not be elicited in the CsA-treated, infected mice at 6 or 12 days after infection. Cytotoxic-T-cell (Tc-cell) activity was present in the lungs of such mice though its appearance was delayed and the activity recovered was less than that of the control infected mice. If administered with a dose of virus lethal for normal mice. CSA-treated mice survived, probably due to the greatly reduced level of immunopathological damage in the infected lung.
Similar articles
-
The generation of effector T cells in influenza A-infected, cyclosporine A-treated mice.Cell Immunol. 1985 Oct 15;95(2):340-8. doi: 10.1016/0008-8749(85)90321-1. Cell Immunol. 1985. PMID: 3876162
-
Humoral and cellular responses of mice to infection with a cold-adapted influenza A virus variant.Infect Immun. 1982 Oct;38(1):218-25. doi: 10.1128/iai.38.1.218-225.1982. Infect Immun. 1982. PMID: 6982860 Free PMC article.
-
Influenza virus-specific T cells fail to reduce lung virus titres in cyclosporin-treated, infected mice.Scand J Immunol. 1985 Jul;22(1):99-103. doi: 10.1111/j.1365-3083.1985.tb01864.x. Scand J Immunol. 1985. PMID: 3875147
-
Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity.Eur J Immunol. 1984 Apr;14(4):350-6. doi: 10.1002/eji.1830140414. Eur J Immunol. 1984. PMID: 6609824
-
Mechanisms of augmented resistance of cyclosporin A-treated mice to influenza virus infection by trehalose-6,6'-dimycolate.Microbiol Immunol. 1992;36(10):1061-75. doi: 10.1111/j.1348-0421.1992.tb02110.x. Microbiol Immunol. 1992. PMID: 1282653
Cited by
-
Effect of cyclosporin A on an experimental chronic viral infection of the central nervous system.J Neuroimmunol. 1989 Jan;21(1):49-57. doi: 10.1016/0165-5728(89)90158-6. J Neuroimmunol. 1989. PMID: 2535702 Free PMC article.
-
Augmentation of delayed-type hypersensitivity to high dose sheep erythrocytes by cyclosporin A in the mouse: influence of drug dosage and route of administration and analysis of spleen cell populations.Clin Exp Immunol. 1988 Jan;71(1):149-54. Clin Exp Immunol. 1988. PMID: 3349644 Free PMC article.
-
A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials.Life Sci. 2020 Aug 1;254:117775. doi: 10.1016/j.lfs.2020.117775. Epub 2020 May 11. Life Sci. 2020. PMID: 32418894 Free PMC article.
-
Drug repurposing for new, efficient, broad spectrum antivirals.Virus Res. 2019 Apr 15;264:22-31. doi: 10.1016/j.virusres.2019.02.011. Epub 2019 Feb 19. Virus Res. 2019. PMID: 30794895 Free PMC article. Review.
-
Mechanism of recovery from acute virus infection. II. Effect of treatment of mice with cyclosporin A on their ability to eliminate the lymphocytic choriomeningitis virus.Med Microbiol Immunol. 1985;174(4):187-96. doi: 10.1007/BF02123695. Med Microbiol Immunol. 1985. PMID: 3877860
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources