Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner
- PMID: 29779889
- DOI: 10.1016/j.stem.2018.04.016
Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner
Abstract
One hallmark of adult neurogenesis is its adaptability to environmental influences. Here, we uncovered the epithelial sodium channel (ENaC) as a key regulator of adult neurogenesis as its deletion in neural stem cells (NSCs) and their progeny in the murine subependymal zone (SEZ) strongly impairs their proliferation and neurogenic output in the olfactory bulb. Importantly, alteration of fluid flow promotes proliferation of SEZ cells in an ENaC-dependent manner, eliciting sodium and calcium signals that regulate proliferation via calcium-release-activated channels and phosphorylation of ERK. Flow-induced calcium signals are restricted to NSCs in contact with the ventricular fluid, thereby providing a highly specific mechanism to regulate NSC behavior at this special interface with the cerebrospinal fluid. Thus, ENaC plays a central role in regulating adult neurogenesis, and among multiple modes of ENaC function, flow-induced changes in sodium signals are critical for NSC biology.
Keywords: ENaC; adult neurogenesis; fluid flow; neural stem cells; proliferation.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment in
-
Go with the Flow: Cerebrospinal Fluid Flow Regulates Neural Stem Cell Proliferation.Cell Stem Cell. 2018 Jun 1;22(6):783-784. doi: 10.1016/j.stem.2018.05.015. Cell Stem Cell. 2018. PMID: 29859165
Similar articles
-
Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone.J Neurosci. 2017 Dec 6;37(49):11867-11880. doi: 10.1523/JNEUROSCI.0001-17.2017. Epub 2017 Nov 3. J Neurosci. 2017. PMID: 29101245 Free PMC article.
-
Go with the Flow: Cerebrospinal Fluid Flow Regulates Neural Stem Cell Proliferation.Cell Stem Cell. 2018 Jun 1;22(6):783-784. doi: 10.1016/j.stem.2018.05.015. Cell Stem Cell. 2018. PMID: 29859165
-
Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells.Mol Biol Cell. 2011 Jun 15;22(12):1960-70. doi: 10.1091/mbc.E11-01-0053. Epub 2011 Apr 20. Mol Biol Cell. 2011. PMID: 21508317 Free PMC article.
-
Protein S Regulates Neural Stem Cell Quiescence and Neurogenesis.Stem Cells. 2017 Mar;35(3):679-693. doi: 10.1002/stem.2522. Epub 2016 Nov 8. Stem Cells. 2017. PMID: 27753164
-
Paracrine regulation of neural stem cells in the subependymal zone.Arch Biochem Biophys. 2013 Jun;534(1-2):11-9. doi: 10.1016/j.abb.2012.10.001. Epub 2012 Oct 13. Arch Biochem Biophys. 2013. PMID: 23073070 Review.
Cited by
-
An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis.EMBO Rep. 2024 Jan;25(1):351-377. doi: 10.1038/s44319-023-00016-2. Epub 2023 Dec 20. EMBO Rep. 2024. PMID: 38177913 Free PMC article.
-
Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development.PLoS Genet. 2018 Nov 26;14(11):e1007817. doi: 10.1371/journal.pgen.1007817. eCollection 2018 Nov. PLoS Genet. 2018. PMID: 30475797 Free PMC article.
-
Secondary Brain Injury Following Neonatal Intraventricular Hemorrhage: The Role of the Ciliated Ependyma.Front Pediatr. 2022 Jun 30;10:887606. doi: 10.3389/fped.2022.887606. eCollection 2022. Front Pediatr. 2022. PMID: 35844746 Free PMC article. Review.
-
From Neural Tube Formation Through the Differentiation of Spinal Cord Neurons: Ion Channels in Action During Neural Development.Front Mol Neurosci. 2020 Apr 24;13:62. doi: 10.3389/fnmol.2020.00062. eCollection 2020. Front Mol Neurosci. 2020. PMID: 32390800 Free PMC article.
-
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.EMBO J. 2019 Sep 2;38(17):e100481. doi: 10.15252/embj.2018100481. Epub 2019 Jul 15. EMBO J. 2019. PMID: 31304985 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
