Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;85(21):7972-6.
doi: 10.1073/pnas.85.21.7972.

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells

E J Bowman  1 , A Siebers, K Altendorf
Affiliations

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells

E J Bowman et al. Proc Natl Acad Sci U S A. 1988 Nov.

Abstract

Various membrane ATPases have been tested for their sensitivity to bafilomycin A1, a macrolide antibiotic. F1F0 ATPases from bacteria and mitochondria are not affected by this antibiotic. In contrast, E1E2 ATPases--e.g., the K+-dependent (Kdp) ATPase from Escherichia coli, the Na+,K+-ATPase from ox brain, and the Ca2+-ATPase from sarcoplasmic reticulum--are moderately sensitive to this inhibitor. Finally, membrane ATPases from Neurospora vacuoles, chromaffin granules, and plant vacuoles are extremely sensitive. From this we conclude that bafilomycin A1 is a valuable tool for distinguishing among the three different types of ATPases and represents the first relatively specific potent inhibitor of vacuolar ATPases.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Anal Biochem. 1976 Mar;71(1):209-13 - PubMed
    1. Anal Biochem. 1975 Mar;64(1):136-41 - PubMed
    1. J Biol Chem. 1985 Jul 25;260(15):8726-30 - PubMed
    1. Biochem J. 1985 Nov 1;231(3):557-64 - PubMed
    1. Plant Physiol. 1985 Jun;78(2):327-33 - PubMed

Publication types

MeSH terms