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. 2018 May/Jun;47(5):e27-e29.
doi: 10.1097/MPA.0000000000001041.

Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation

Mayumi Naramura  1 , Amarnath Natarajan
Affiliations

Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation

Mayumi Naramura et al. Pancreas. 2018 May/Jun.
No abstract available

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Conflict of interest statement

Conflict of interest

The authors declare no conflict of interest

Figures

FIGURE 1
FIGURE 1
A, Schematic representation of mutant alleles used in this study. B, Macroscopic appearance of the abdominal tumor in the nine day old Pdx1-Cre; Kras G12D; caIKKβ mouse. The arrow indicates the tumor (demarcated with the dotted white line). H&E stain of the tumor. C, Anti-FLAG antibody stain (brown) of the tumor. Anti-GFP antibody stain (brown) of the tumor. D, Kaplan-Meier survival analysis of Pdx1-Cre; Kras G12D (blue), Pdx1-Cre; Kras G12D; Trp53 flox (gold), Pdx1-Cre; Kras G12D; caIKKβ (red), and their littermates (black). E, Pancreatic tumors from Pdx1-Cre; Kras G12D; Trp53 flox (top) and Pdx1-Cre; Kras G12D; caIKKβ (bottom) were stained with antibodies against cytokeratin 19 (left) and MUC5AC (right).
See this image and copyright information in PMC

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