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Case Reports
. 2018 Jun;28(6):888-889.
doi: 10.1017/S1047951118000379. Epub 2018 Apr 25.

Successful treatment of disseminated adenovirus infection with cidofovir and intravenous immunoglobulin in an infant following heart transplant

Ryan M Serrano  1 , Robert K Darragh  1 , John J Parent  1
Affiliations
Case Reports

Successful treatment of disseminated adenovirus infection with cidofovir and intravenous immunoglobulin in an infant following heart transplant

Ryan M Serrano et al. Cardiol Young. 2018 Jun.

Abstract

For most patients, adenoviruses cause few acute health concerns and are often self-limiting. Patients who are immunocompromised or immunosuppressed, however, are at risk for disseminated adenovirus and suffer high morbidity and mortality, without well-defined treatment options. We report the case of a 9-month-old boy who was successfully treated for disseminated adenovirus infection with intravenous immunoglobulin and cidofovir 3 months post heart transplant, tailored to serum adenoviral load and clinical response. We emphasise the importance of early identification, monitoring, and a potentially novel treatment in the paediatric cardiac transplant population with disseminated adenovirus infection.

Keywords: Cardiac transplantation; IVIG; adenovirus.

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