Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

doi:10.1021/jacs.8b03001

. 2018 May 9;140(18):5909-5913.

doi: 10.1021/jacs.8b03001. Epub 2018 Apr 27.

Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

Heemin Kang¹, Hee Joon Jung^{2

3

4}, Dexter Siu Hong Wong¹, Sung Kyu Kim^{2

3

4}, Sien Lin⁵, Kai Fung Chan, Li Zhang, Gang Li⁵, Vinayak P Dravid^{2

3

4}, Liming Bian^{1

6}

Affiliations

¹ Department of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
² Department of Materials Science and Engineering , Northwestern University , Evanston , Illinois 60208 , United States.
³ International Institute for Nanotechnology , Evanston , Illinois 60208 , United States.
⁴ NUANCE Center , Northwestern University , Evanston , Illinois 60208 , United States.
⁵ Department of Orthopaedics & Traumatology, Faculty of Medicine , The Chinese University of Hong Kong , Prince of Wales Hospital, Shatin , Hong Kong , China.
⁶ Translational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong , China.

PMID: 29681155
DOI: 10.1021/jacs.8b03001

Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

Heemin Kang et al. J Am Chem Soc. 2018.

. 2018 May 9;140(18):5909-5913.

doi: 10.1021/jacs.8b03001. Epub 2018 Apr 27.

Authors

Heemin Kang¹, Hee Joon Jung^{2

3

4}, Dexter Siu Hong Wong¹, Sung Kyu Kim^{2

3

4}, Sien Lin⁵, Kai Fung Chan, Li Zhang, Gang Li⁵, Vinayak P Dravid^{2

3

4}, Liming Bian^{1

6}

Affiliations

¹ Department of Biomedical Engineering , The Chinese University of Hong Kong , Hong Kong , China.
² Department of Materials Science and Engineering , Northwestern University , Evanston , Illinois 60208 , United States.
³ International Institute for Nanotechnology , Evanston , Illinois 60208 , United States.
⁴ NUANCE Center , Northwestern University , Evanston , Illinois 60208 , United States.
⁵ Department of Orthopaedics & Traumatology, Faculty of Medicine , The Chinese University of Hong Kong , Prince of Wales Hospital, Shatin , Hong Kong , China.
⁶ Translational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University , The Third Affiliated Hospital of Guangzhou Medical University , Guangzhou , Guangdong , China.

PMID: 29681155
DOI: 10.1021/jacs.8b03001

Abstract

Remote, noninvasive, and reversible control over the nanoscale presentation of bioactive ligands, such as Arg-Gly-Asp (RGD) peptide, is highly desirable for temporally regulating cellular functions in vivo. Herein, we present a novel strategy for physically uncaging RGD using a magnetic field that allows safe and deep tissue penetration. We developed a heterodimeric nanoswitch consisting of a magnetic nanocage (MNC) coupled to an underlying RGD-coated gold nanoparticle (AuNP) via a long flexible linker. Magnetically controlled movement of MNC relative to AuNP allowed reversible uncaging and caging of RGD that modulate physical accessibility of RGD for integrin binding, thereby regulating stem cell adhesion, both in vitro and in vivo. Reversible RGD uncaging by the magnetic nanoswitch allowed temporal regulation of stem cell adhesion, differentiation, and mechanosensing. This physical and reversible RGD uncaging utilizing heterodimeric magnetic nanoswitch is unprecedented and holds promise in the remote control of cellular behaviors in vivo.

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Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

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Remote Control of Heterodimeric Magnetic Nanoswitch Regulates the Adhesion and Differentiation of Stem Cells

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