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Review
. 2018 Jun 11;33(6):954-964.
doi: 10.1016/j.ccell.2018.03.004. Epub 2018 Apr 12.

The Intestinal Microbiota in Colorectal Cancer

Herbert Tilg  1 , Timon E Adolph  2 , Romana R Gerner  3 , Alexander R Moschen  3
Affiliations
Free article
Review

The Intestinal Microbiota in Colorectal Cancer

Herbert Tilg et al. Cancer Cell. .
Free article

Abstract

Experimental evidence from the past years highlights a key role for the intestinal microbiota in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on microbial composition and provides risk for developing colorectal carcinoma (CRC). Large metagenomic studies in human CRC associated microbiome signatures with the colorectal adenoma-carcinoma sequence, suggesting a fundamental role of the intestinal microbiota in the evolution of gastrointestinal malignancy. Basic science established a critical function for the intestinal microbiota in promoting tumorigenesis. Further studies are needed to decipher the mechanisms of tumor promotion and microbial co-evolution in CRC, which may be exploited therapeutically in the future.

Keywords: bacteria; cancer; immunity; inflammation; microbiota.

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