The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

doi:10.1016/j.jalz.2018.03.002

Review

. 2018 Apr;14(4):563-575.

doi: 10.1016/j.jalz.2018.03.002.

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

David S Knopman¹, Samantha Budd Haeberlein², Maria C Carrillo³, James A Hendrix⁴, Geoff Kerchner⁵, Richard Margolin⁶, Paul Maruff⁷, David S Miller⁸, Gary Tong⁹, Maria B Tome¹⁰, Melissa E Murray¹¹, Peter T Nelson¹², Mary Sano¹³, Niklas Mattsson¹⁴, David L Sultzer¹⁵, Thomas J Montine¹⁶, Clifford R Jack Jr¹, Hartmuth Kolb¹⁷, Ronald C Petersen¹, Prashanthi Vemuri¹, Megan Zoschg Canniere¹⁸, Julie A Schneider¹⁹, Susan M Resnick²⁰, Gary Romano²¹, Argonde Corien van Harten²², David A Wolk²³, Lisa J Bain²⁴, Eric Siemers²⁵

Affiliations

¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
² Biogen, Cambridge, MA, USA.
³ Alzheimer's Association, Chicago, IL, USA.
⁴ Alzheimer's Association, Chicago, IL, USA. Electronic address: jhendrix@alz.org.
⁵ Genentech, Inc., South San Francisco, CA, USA.
⁶ Pfizer, New York, NY, USA.
⁷ Cogstate Ltd, Melbourne, Victoria, Australia.
⁸ Bracket, Wayne, PA, USA.
⁹ Lundbeck, Deerfield, IL, USA.
¹⁰ European Medicines Agency (EMA), London, UK.
¹¹ Mayo Clinic, Jacksonville, FL, USA.
¹² University of Kentucky, Lexington, KY, USA.
¹³ Mount Sinai School of Medicine, New York, NY, USA.
¹⁴ Clinical Memory Research Unit, Lund University, Lund, Sweden.
¹⁵ David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹⁶ Department of Pathology, Stanford University, Stanford, CA, USA.
¹⁷ Janssen Research and Development, San Diego, CA, USA.
¹⁸ Hoffmann-La Roche, Inc., Basel, Switzerland.
¹⁹ Rush University Medical Center, Chicago, IL, USA.
²⁰ National Institute on Aging, Baltimore, MD, USA.
²¹ Janssen R&D, Titusville, NJ, USA.
²² VU University Medical Center, Amsterdam, the Netherlands.
²³ Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
²⁴ Independent Science Writer, Elverson, PA, USA.
²⁵ Eli Lilly and Company, Indianapolis, IN, USA.

PMID: 29653607
PMCID: PMC6747694
DOI: 10.1016/j.jalz.2018.03.002

Review

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

David S Knopman et al. Alzheimers Dement. 2018 Apr.

. 2018 Apr;14(4):563-575.

doi: 10.1016/j.jalz.2018.03.002.

Authors

Affiliations

¹ Department of Neurology, Mayo Clinic, Rochester, MN, USA.
² Biogen, Cambridge, MA, USA.
³ Alzheimer's Association, Chicago, IL, USA.
⁴ Alzheimer's Association, Chicago, IL, USA. Electronic address: jhendrix@alz.org.
⁵ Genentech, Inc., South San Francisco, CA, USA.
⁶ Pfizer, New York, NY, USA.
⁷ Cogstate Ltd, Melbourne, Victoria, Australia.
⁸ Bracket, Wayne, PA, USA.
⁹ Lundbeck, Deerfield, IL, USA.
¹⁰ European Medicines Agency (EMA), London, UK.
¹¹ Mayo Clinic, Jacksonville, FL, USA.
¹² University of Kentucky, Lexington, KY, USA.
¹³ Mount Sinai School of Medicine, New York, NY, USA.
¹⁴ Clinical Memory Research Unit, Lund University, Lund, Sweden.
¹⁵ David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
¹⁶ Department of Pathology, Stanford University, Stanford, CA, USA.
¹⁷ Janssen Research and Development, San Diego, CA, USA.
¹⁸ Hoffmann-La Roche, Inc., Basel, Switzerland.
¹⁹ Rush University Medical Center, Chicago, IL, USA.
²⁰ National Institute on Aging, Baltimore, MD, USA.
²¹ Janssen R&D, Titusville, NJ, USA.
²² VU University Medical Center, Amsterdam, the Netherlands.
²³ Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
²⁴ Independent Science Writer, Elverson, PA, USA.
²⁵ Eli Lilly and Company, Indianapolis, IN, USA.

PMID: 29653607
PMCID: PMC6747694
DOI: 10.1016/j.jalz.2018.03.002

Abstract

The Alzheimer's Association's Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease. The meeting allowed experts in the field from academia, industry, and government to provide perspectives on the new National Institute on Aging and the Alzheimer's Association Research Framework. This review will summarize the "A, T, N System" (Amyloid, Tau, and Neurodegeneration) using biomarkers and how this may be applied to clinical research and drug development. In addition, challenges and barriers to the potential adoption of this new framework will be discussed. Finally, future directions for research will be proposed.

Keywords: Alzheimer's disease; Amyloid; Biomarkers; Clinical trials; Neurodegeneration; Tau.

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References

1. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:270–9. - PMC - PubMed
1. Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:257–62. - PMC - PubMed
1. McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:263–9. - PMC - PubMed
1. Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:280–92. - PMC - PubMed
1. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6:734–46. - PubMed

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[1] Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:270–9. - PMC - PubMed

[2] Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:270–9. - PMC - PubMed

[3] Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:257–62. - PMC - PubMed

[4] Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:257–62. - PMC - PubMed

[5] McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:263–9. - PMC - PubMed

[6] McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:263–9. - PMC - PubMed

[7] Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:280–92. - PMC - PubMed

[8] Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:280–92. - PMC - PubMed

[9] Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6:734–46. - PubMed

[10] Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6:734–46. - PubMed

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The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

Affiliations

The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable

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Abstract

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