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. 2018 Apr 12;10(4):474.
doi: 10.3390/nu10040474.

MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches

Antonino De Lorenzo  1   2 , Annalisa Noce  3 , Eleonora Moriconi  4   5   6 , Tiziana Rampello  7 , Giulia Marrone  8   9 , Nicola Di Daniele  10 , Valentina Rovella  11
Affiliations

MOSH Syndrome (Male Obesity Secondary Hypogonadism): Clinical Assessment and Possible Therapeutic Approaches

Antonino De Lorenzo et al. Nutrients. .

Abstract

Male obesity secondary hypogonadism (MOSH) impairs fertility, sexual function, bone mineralization, fat metabolism, cognitive function, deteriorates muscle mass and alters body composition. The aim of this pilot study was to evaluate the effect of dietary intervention and physical activity on the MOSH patient's hormonal profile after a 10% weight loss compared to baseline. Fourteen male patients were enrolled. Hormonal, lipid, glycemic profiles and body composition were determined at baseline and after a 10% weight loss. Aging Male Symptoms Scale (AMS) and Yale Food Addiction Scale (YFAS) were administered to patients in order to investigate hypogonadal symptoms and food addiction. Compared to baseline, a significant increase of Total Testosterone (TT) (300.2 ± 79.5 ng/dL vs. 408.3 ± 125.9 ng/dL, p = 0.002, 95% CI 26.8; 167.7) and a reduction of 17-Beta Estradiol level (48.3 ± 14.9 pg/mL vs. 39.2 ± 15.2 pg/mL, p = 0.049, 95% CI 3.1; 0.0) were observed. Total Fat Mass (FM) percentage, android and gynoid fat mass percentage (39.2 ± 6.4% vs. 36.2 ± 5.8%, p = 0.0001, 95% CI 22.5; 62.3; 51.5 ± 6.8% vs. 47.6 ± 6.8%, p = 0.001, 95% CI 0.6; 1.8, vs. 39.2 ± 6.2% vs. 36.5 ± 6.3% p = 0.0001, 95% CI 0.9; 2.0 respectively) were significantly decreased after nutritional intervention. In addition, total Fat Free Mass (FFM) in kg was significantly reduced after 10% weight loss (62.3 ± 2.8 kg vs. 60.3 ± 7.7 kg, p = 0.002, 95% CI 45.0; 93.0). Lifestyle changes, specifically dietotherapy and physical activity, induce positive effects on hypogonadism due to obesity.

Keywords: Aromatase activity; MOSH syndrome; Testosterone/17-Beta Estradiol Ratio; food addiction; lifestyle change.

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Conflict of interest statement

The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

Figures

Figure 1
Figure 1
Spaghetti plot of hormonal profile at baseline and after 10% weight loss with individual patient trajectories indicated by colored lines. (a) TT; (b) E2; (c) aromatase enzyme activity, expressed as TT/E2.
See this image and copyright information in PMC

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References

    1. De Lorenzo A., Soldati L., Sarlo F., Calvani M., Di Lorenzo N., Di Renzo L. New obesity classification criteria as a tool for bariatric surgery indication. World J. Gastroenterol. 2016;22:681–703. doi: 10.3748/wjg.v22.i2.681. - DOI - PMC - PubMed
    1. Di Daniele N., Noce A., Vidiri M.F., Moriconi E., Marrone G., Annicchiarico-Petruzzelli M., D’Urso G., Tesauro M., Rovella V., De Lorenzo A. Impact of Mediterranean diet on metabolic syndrome, cancer and longevity. Oncotarget. 2017;8:8947–8979. doi: 10.18632/oncotarget.13553. - DOI - PMC - PubMed
    1. NCD Risk Factor Collaboration Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet. 2016;387:1377–1396. - PMC - PubMed
    1. Ng M., Fleming T., Robinson M., Thomson B., Graetz N., Margono C., Mullany E.C., Biryukov S., Abbafati C., Abera S.F., et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: A systematic analysis for the global burden of disease study 2013. Lancet. 2014;384:766–781. doi: 10.1016/S0140-6736(14)60460-8. - DOI - PMC - PubMed
    1. Nieschlag E., Hermann M., Nieschlag S. Andrology: Male Reproductive Health and Dysfunction. 3rd ed. Springer; Berlin/Heidelberg, Germany: 2010.

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