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Review
. 2018 Apr;83(4):402-410.
doi: 10.1134/S0006297918040119.

Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes

F B Sall  1 , D Germini, A P Kovina, V Ribrag, J Wiels, A O Toure, O V Iarovaia, M Lipinski, Y Vassetzky
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Free article
Review

Effect of Environmental Factors on Nuclear Organization and Transformation of Human B Lymphocytes

F B Sall et al. Biochemistry (Mosc). 2018 Apr.
Free article

Abstract

Chromosomal translocations have long been known for their association with malignant transformation, particularly in hematopoietic disorders such as B-cell lymphomas. In addition to the physiological process of maturation, which creates double strand breaks in immunoglobulin gene loci, environmental factors including the Epstein-Barr and human immunodeficiency viruses, malaria-causing parasites (Plasmodium falciparum), and plant components (Euphorbia tirucalli latex) can trigger a reorganization of the nuclear architecture and DNA damage that together will facilitate the occurrence of deleterious chromosomal rearrangements.

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