Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Dec 9;14(23):9445-56.
doi: 10.1093/nar/14.23.9445.

Adenovirus-2 E1a and E1b gene products regulate enhancer mediated transcription

V Natarajan
Free PMC article

Adenovirus-2 E1a and E1b gene products regulate enhancer mediated transcription

V Natarajan. Nucleic Acids Res. .
Free PMC article

Abstract

We have shown that adenovirus-2 early region 1 gene products in trans and the SV40 enhancer in cis have an additive effect in stimulating transcription from adenovirus IVa2 and major late promoters (Natarajan, V. and Salzman, N. P., Nucleic Acids Research 13, 4067, 1985). In the present study, we show that both the E1a and E1b gene products are necessary for this stimulatory effect on enhancer mediated transcription. In the absence of E1b region, the transcription is strongly suppressed by E1a. Transcription from E1a promoter is also stimulated 4-5 fold in the presence of E1b region. The data suggest that 21K protein coded by the E1b region modulates transcription from the E1a promoter and the action of E1a gene products on transcription from other promoters.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Virol. 1979 Aug;31(2):360-9 - PubMed
    1. Mol Cell Biol. 1985 Oct;5(10):2684-96 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3665-9 - PubMed
    1. Annu Rev Biochem. 1981;50:349-83 - PubMed
    1. J Mol Biol. 1981 Jun 25;149(2):189-221 - PubMed