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. 2017 Dec 14;4(1):85-96.
doi: 10.1002/osp4.138. eCollection 2018 Feb.

Association of interleukin-6 polymorphisms with obesity or metabolic traits in young Mexican-Americans

K Boeta-Lopez  1 , J Duran  1 , D Elizondo  1 , E Gonzales  1 , A Rentfro  1 , A E Schwarzbach  1 , S Nair  1
Affiliations

Association of interleukin-6 polymorphisms with obesity or metabolic traits in young Mexican-Americans

K Boeta-Lopez et al. Obes Sci Pract. .

Abstract

Objective: The objective of the study is to investigate the association of interleukin-6 (IL6) promoter single-nucleotide polymorphisms rs1800797 (-597 G/A) and rs1800796 (-572 G/C) with obesity or metabolic syndrome in Mexican-Americans.

Methods: The rs1800797 and rs1800796 single-nucleotide polymorphisms were genotyped in Mexican-Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high-sensitive C-reactive protein (hs-CRP).

Results: Significant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs-CRP levels. The rs1800797 variant showed no associations with metabolic traits but was associated with higher IL6 levels and lower hs-CRP levels.

Conclusions: Findings in this study support the anti-inflammatory, anti-obesity and glucose homeostatic roles of IL6 in Mexican-American youth.

Keywords: Genetics; inflammation; interleukin‐6; obesity.

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Figures

Figure 1
Figure 1
Comparison of mean plasma interleukin‐6 (IL6) and high‐sensitive C‐reactive protein (hs‐CRP) levels between genotypes for each single‐nucleotide polymorphism. A. Plasma IL6 and hs‐CRP levels were compared between rs1800797 genotypes. Plasma IL6 was significantly higher in rs1800797 A (protective allele against obesity and metabolic traits)‐carriers than in G‐homozygotes (P = 0.002), and hs‐CRP was significantly lower in rs1800797 A‐carriers than in G‐homozygotes (P = 0.04). B. Plasma IL6 and hs‐CRP levels were compared between rs1800796 genotypes. Plasma IL6 was significantly lower in rs1800796 C (risk allele for obesity and metabolic traits)‐homozygotes than in G‐carriers (P = 6.6e−07), and hs‐CRP was significantly higher in C‐carriers than in G‐homozygous (P = 0.01).
Figure 2
Figure 2
Comparison of liver enzyme (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) levels for each interleukin‐6 (IL6) single‐nucleotide polymorphism genotype. A. Liver enzymes were compared between rs1800797 genotypes. Levels of liver enzymes did not differ between rs1800797 genotypes, but a trend for higher plasma levels of liver enzymes was observed in rs1800797 GG (trend for higher hs‐CRP and lower IL6) genotypes. B. Liver enzymes were compared between rs1800796 genotypes. Plasma levels of liver enzymes did not differ between rs1800796 genotypes, but a trend of higher plasma levels of liver enzymes was observed in rs1800796 C (risk allele for waist circumference, homeostasis model assessment of insulin resistance, higher hs‐CRP and lower IL6)‐carriers. White circles refer to outliers; black circles refer to mean.
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