TCRαβ+CD3+CD4-CD8- (double negative) T cells in autoimmunity
- PMID: 29428806
- DOI: 10.1016/j.autrev.2018.02.001
TCRαβ+CD3+CD4-CD8- (double negative) T cells in autoimmunity
Abstract
TCRαβ+CD3+CD4-CD8- "double negative" (DN) T cells comprise a small subset of mature peripheral T cells. The origin and function of DN T cells are somewhat unclear and discussed controversially. While DN T cells resemble a rare and heterogeneous T cell subpopulation in healthy individuals, numbers of TCRαβ+ DN T cells are expanded in several inflammatory conditions, where they also exhibit distinct effector phenotypes and infiltrate inflamed tissues. Thus, DN T cells may be involved in systemic inflammation and tissue damage in autoimmune/inflammatory conditions, including SLE, Sjögren's syndrome, and psoriasis. Here, the current understanding of the origin and phenotype of DN T cells, and their role in the instruction of immune responses, autoimmunity and inflammation will be discussed in health and disease.
Keywords: DN T cells; Double negative T cells; Effector T cells; Inflammation; Psoriasis; SLE.
Copyright © 2018 Elsevier B.V. All rights reserved.
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