Nanomedicine: An effective tool in cancer therapy

doi:10.1016/j.ijpharm.2018.02.007

Review

. 2018 Apr 5;540(1-2):132-149.

doi: 10.1016/j.ijpharm.2018.02.007. Epub 2018 Feb 7.

Nanomedicine: An effective tool in cancer therapy

Saima Aftab¹, Afzal Shah², Akhtar Nadhman¹, Sevinc Kurbanoglu³, Sibel Aysıl Ozkan³, Dionysios D Dionysiou⁴, Shyam S Shukla⁵, Tejraj M Aminabhavi⁶

Affiliations

¹ Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
² Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey. Electronic address: afzals_qau@yahoo.com.
³ Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey.
⁴ Environmental Engineering and Science Program, Department of Biomedical, Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221-0012, USA.
⁵ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA.
⁶ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA. Electronic address: aminabhavit@gmail.com.

PMID: 29427746
DOI: 10.1016/j.ijpharm.2018.02.007

Review

Nanomedicine: An effective tool in cancer therapy

Saima Aftab et al. Int J Pharm. 2018.

. 2018 Apr 5;540(1-2):132-149.

doi: 10.1016/j.ijpharm.2018.02.007. Epub 2018 Feb 7.

Authors

Saima Aftab¹, Afzal Shah², Akhtar Nadhman¹, Sevinc Kurbanoglu³, Sibel Aysıl Ozkan³, Dionysios D Dionysiou⁴, Shyam S Shukla⁵, Tejraj M Aminabhavi⁶

Affiliations

¹ Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan.
² Department of Chemistry, Quaid-i-Azam University, 45320 Islamabad, Pakistan; Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey. Electronic address: afzals_qau@yahoo.com.
³ Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandogan, 06100 Ankara, Turkey.
⁴ Environmental Engineering and Science Program, Department of Biomedical, Chemical and Environmental Engineering, University of Cincinnati, Cincinnati, OH 45221-0012, USA.
⁵ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA.
⁶ Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX 77710, USA. Electronic address: aminabhavit@gmail.com.

PMID: 29427746
DOI: 10.1016/j.ijpharm.2018.02.007

Abstract

Various types of nanoparticles (NPs) have been used in delivering anticancer drugs to the site of action. This area has become more attractive in recent years due to optimal size and negligible undesirable side effects caused by the NPs. The focus of this review is to explore various types of NPs and their surface/chemical modifications as well as attachment of targeting ligands for tuning their properties in order to facilitate targeted delivery to the cancer sites in a rate-controlled manner. Heme compatibility, biodistribution, longer circulation time, hydrophilic lipophilic balance for high bioavailability, prevention of drug degradation and leakage are important in transporting drugs to the targeted cancer sites. The review discusses advantages of polymeric, magnetic, gold, and mesoporous silica NPs in delivering chemotherapeutic agents over the conventional dosage formulations along with their shortcomings/risks and possible solutions/alternatives.

Keywords: Blood brain barrier; Cancer therapy; Controlled release; Nanomedicine; Targeted drug delivery.

PubMed Disclaimer

Cited by

Preparation and Evaluation of Cabazitaxel-Loaded Bovine Serum Albumin Nanoparticles for Prostate Cancer.
Wan Z, Xie F, Wang L, Zhang G, Zhang H. Wan Z, et al. Int J Nanomedicine. 2020 Jul 29;15:5333-5344. doi: 10.2147/IJN.S258856. eCollection 2020. Int J Nanomedicine. 2020. PMID: 32801692 Free PMC article.
Evaluation of Intestinal Absorption Mechanism and Pharmacokinetics of Curcumin-Loaded Galactosylated Albumin Nanoparticles.
Huang Y, Deng S, Luo X, Liu Y, Xu W, Pan J, Wang M, Xia Z. Huang Y, et al. Int J Nanomedicine. 2019 Dec 10;14:9721-9730. doi: 10.2147/IJN.S229992. eCollection 2019. Int J Nanomedicine. 2019. PMID: 31849464 Free PMC article.
Novel Delivery of Mitoxantrone with Hydrophobically Modified Pullulan Nanoparticles to Inhibit Bladder Cancer Cell and the Effect of Nano-drug Size on Inhibition Efficiency.
Tao X, Tao T, Wen Y, Yi J, He L, Huang Z, Nie Y, Yao X, Wang Y, He C, Yang X. Tao X, et al. Nanoscale Res Lett. 2018 Oct 30;13(1):345. doi: 10.1186/s11671-018-2769-x. Nanoscale Res Lett. 2018. PMID: 30377872 Free PMC article.
GM-CSF augmented the photothermal immunotherapeutic outcome of self-driving gold nanoparticles against a mouse CT-26 colon tumor model.
Dai J, Li J, Zhang Y, Wen Q, Lu Y, Fan Y, Zeng F, Qian Z, Zhang Y, Fu S. Dai J, et al. Biomater Res. 2023 Oct 23;27(1):105. doi: 10.1186/s40824-023-00430-6. Biomater Res. 2023. PMID: 37872620 Free PMC article.
FMSP-Nanoparticles Induced Cell Death on Human Breast Adenocarcinoma Cell Line (MCF-7 Cells): Morphometric Analysis.
Khan FA, Akhtar S, Almofty SA, Almohazey D, Alomari M. Khan FA, et al. Biomolecules. 2018 May 23;8(2):32. doi: 10.3390/biom8020032. Biomolecules. 2018. PMID: 29882888 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
- Ovid Technologies, Inc.
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Nanomedicine: An effective tool in cancer therapy

Affiliations

Nanomedicine: An effective tool in cancer therapy

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources