Mechanistic aspects of epigenetic dysregulation in SLE
- PMID: 29425851
- DOI: 10.1016/j.clim.2018.02.002
Mechanistic aspects of epigenetic dysregulation in SLE
Abstract
Epigenetic events have been linked with disease expression in individuals genetically predisposed to the development of systemic lupus erythematosus (SLE), a severe systemic autoimmune/inflammatory disease. Altered DNA methylation and hydroxymethylation as well as histone modifications mediate changes in chromatin accessibility and gene expression in immune cells from SLE patients. Defective epigenetic control contributes to uncontrolled expression of inflammatory mediators, including cytokines and co-receptors, resulting in systemic inflammation and tissue damage. While the pathophysiological involvement of epigenetic changes in SLE has been accepted for some time, we only recently started to investigate and understand molecular events contributing to epigenetic dysregulation. Here, epigenetic alterations will be discussed with a focus on underling molecular events that may be target of preventative measures or future treatment strategies.
Keywords: CREMα; Chromatin; DNA hydroxymethylation; DNA methylation; Environment; Epigenetic; Histone; Inflammation; Remodeling; Systemic lupus erythematosus.
Copyright © 2018 Elsevier Inc. All rights reserved.
Similar articles
-
Epigenetics in SLE.Curr Rheumatol Rep. 2017 Sep;19(9):58. doi: 10.1007/s11926-017-0685-1. Curr Rheumatol Rep. 2017. PMID: 28752494 Free PMC article. Review.
-
Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells.Autoimmunity. 2014 Jun;47(4):234-41. doi: 10.3109/08916934.2013.801462. Epub 2014 Apr 24. Autoimmunity. 2014. PMID: 24762298 Review.
-
Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus.Clin Epigenetics. 2016 Nov 24;8:126. doi: 10.1186/s13148-016-0294-2. eCollection 2016. Clin Epigenetics. 2016. PMID: 27904655 Free PMC article.
-
Epigenetic dysregulation in systemic lupus erythematosus.Autoimmunity. 2014 Jun;47(4):215-9. doi: 10.3109/08916934.2013.844794. Epub 2013 Oct 16. Autoimmunity. 2014. PMID: 24128164 Review.
-
Epigenetic Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus.Int J Mol Sci. 2024 Jan 13;25(2):1019. doi: 10.3390/ijms25021019. Int J Mol Sci. 2024. PMID: 38256093 Free PMC article. Review.
Cited by
-
Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond.Cells. 2019 Sep 30;8(10):1180. doi: 10.3390/cells8101180. Cells. 2019. PMID: 31575058 Free PMC article. Review.
-
Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan.Front Endocrinol (Lausanne). 2019 Apr 29;10:265. doi: 10.3389/fendo.2019.00265. eCollection 2019. Front Endocrinol (Lausanne). 2019. PMID: 31110493 Free PMC article. Review.
-
Effects of Dietary Oleacein Treatment on Endothelial Dysfunction and Lupus Nephritis in Balb/C Pristane-Induced Mice.Antioxidants (Basel). 2023 Jun 19;12(6):1303. doi: 10.3390/antiox12061303. Antioxidants (Basel). 2023. PMID: 37372034 Free PMC article.
-
Demethylation of CDKN2A in systemic lupus erythematosus and rheumatoid arthritis: a blood biomarker for diagnosis and assessment of disease activity.Clin Rheumatol. 2023 Dec;42(12):3387-3395. doi: 10.1007/s10067-023-06736-z. Epub 2023 Aug 19. Clin Rheumatol. 2023. PMID: 37597101
-
The Role of Epigenetics in Autoimmune/Inflammatory Disease.Front Immunol. 2019 Jul 4;10:1525. doi: 10.3389/fimmu.2019.01525. eCollection 2019. Front Immunol. 2019. PMID: 31333659 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
