Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

doi:10.2217/rme-2017-0152

Clinical Trial

. 2018 Apr;13(3):295-307.

doi: 10.2217/rme-2017-0152. Epub 2018 Feb 8.

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

Yang Song¹, Hui Du¹, Chengxiang Dai², Li Zhang², Suke Li², David J Hunter³, Liangjing Lu¹, Chunde Bao¹

Affiliations

¹ Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
² Cellular Biomedicine Group Ltd, Shanghai, China.
³ Rheumatology Department, Royal North Shore Hospital & Institute of Bone & Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.

PMID: 29417902
DOI: 10.2217/rme-2017-0152

Clinical Trial

Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

Yang Song et al. Regen Med. 2018 Apr.

. 2018 Apr;13(3):295-307.

doi: 10.2217/rme-2017-0152. Epub 2018 Feb 8.

Authors

Yang Song¹, Hui Du¹, Chengxiang Dai², Li Zhang², Suke Li², David J Hunter³, Liangjing Lu¹, Chunde Bao¹

Affiliations

¹ Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
² Cellular Biomedicine Group Ltd, Shanghai, China.
³ Rheumatology Department, Royal North Shore Hospital & Institute of Bone & Joint Research, Kolling Institute, University of Sydney, Sydney, Australia.

PMID: 29417902
DOI: 10.2217/rme-2017-0152

Abstract

Aim: This study aimed to evaluate the safety and therapeutic potential of autologous human adipose-derived mesenchymal stem cells (haMSCs) in patients with osteoarthritis.

Materials & methods: Safety and efficacy of haMSCs were preclinically assessed in vitro and in BALB/c-nu nude mice. 18 patients were enrolled and divided into three dose groups: the low-dose, mid-dose and high-dose group (1 × 10⁷, 2 × 10⁷ and 5 × 10⁷ cells, respectively), provided three injections and followed up for 96 weeks.

Results & conclusion: The preclinical study established the safety and efficacy of haMSCs. Intra-articular injections of haMSCs were safe and improved pain, function and cartilage volume of the knee joint, rendering them a promising novel treatment for knee osteoarthritis. The dosage of 5 × 10⁷ haMSCs exhibited the highest improvement (ClinicalTrials.gov Identifier: NCT01809769).

Keywords: MRI; MSC; cartilage; cell therapy; clinical trials; function; intra-articular; mesenchymal stem cells; osteoarthritis; pain.

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Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

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Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections

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