Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review
- PMID: 29356205
- DOI: 10.1002/ptr.6024
Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review
Abstract
Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections. It is widely accepted that medicinal plant heritage is nature gifted, precious, and fueled with the valuable resources for treatment of metabolic and infectious disorders. The aims of this review are to assemble the facts and to conclude the therapeutic potential of medicinal plants in the eradication and management of various viral diseases such as influenza, human immunodeficiency virus (HIV), herpes simplex virus (HSV), hepatitis, and coxsackievirus infections, which have been proven in diverse clinical studies. The articles, published in the English language since 1982 to 2017, were included from Web of Science, Cochrane Library, AMED, CISCOM, EMBASE, MEDLINE, Scopus, and PubMed by using relevant keywords including plants possessing antiviral activity, the antiviral effects of plants, and plants used in viral disorders. The scientific literature mainly focusing on plant extracts and herbal products with therapeutic efficacies against experimental models of influenza, HIV, HSV, hepatitis, and coxsackievirus were included in the study. Pure compounds possessing antiviral activity were excluded, and plants possessing activity against viruses other than viruses in inclusion criteria were excluded. Hundreds of plant extracts with antiviral effect were recognized. However, the data from only 36 families investigated through in vitro and in vivo studies met the inclusion criteria of this review. The inferences from scientific literature review, focusing on potential therapeutic consequences of medicinal plants on experimental models of HIV, HSV, influenza, hepatitis, and coxsackievirus have ascertained the curative antiviral potential of plants. Fifty-four medicinal plants belonging to 36 different families having antiviral potential were documented. Out of 54 plants, 27 individually belong to particular plant families. On the basis of the work of several independent research groups, the therapeutic potential of medicinal plants against listed common viral diseases in the region has been proclaimed. In this context, the herbal formulations as alternative medicine may contribute to the eradication of complicated viral infection significantly. The current review consolidates the data of the various medicinal plants, those are Sambucus nigra, Caesalpinia pulcherrima, and Hypericum connatum, holding promising specific antiviral activities scientifically proven through studies on experimental animal models. Consequently, the original research addressing the development of novel nutraceuticals based on listed medicinal plants is highly recommended for the management of viral disorders.
Keywords: antiviral herbs; antiviral therapy; efficacy; medicinal plants; natural antivirals.
Copyright © 2018 John Wiley & Sons, Ltd.
Similar articles
-
Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens - Current Knowledge and Future Prospects.Curr Drug Metab. 2018;19(3):236-263. doi: 10.2174/1389200219666180129145252. Curr Drug Metab. 2018. PMID: 29380697 Review.
-
Inhibitory effect of medicinal herbs against RNA and DNA viruses.Antivir Chem Chemother. 2004 May;15(3):153-9. doi: 10.1177/095632020401500305. Antivir Chem Chemother. 2004. PMID: 15266897
-
Anti-viral activity of the extracts of a Kenyan medicinal plant Carissa edulis against herpes simplex virus.J Ethnopharmacol. 2006 Mar 8;104(1-2):92-9. doi: 10.1016/j.jep.2005.08.053. Epub 2005 Sep 29. J Ethnopharmacol. 2006. PMID: 16198524
-
[Antiviral activity of extracts of basidiomycetes and humic compounds substances against Human Immunodeficiency Virus (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus 1) and Herpes Simplex Virus (Herpesviridae: Simplexvirus: Human alphaherpesvirus 1)].Vopr Virusol. 2020 Nov 14;65(5):276-283. doi: 10.36233/0507-4088-2020-65-5-4. Vopr Virusol. 2020. PMID: 33533211 Russian.
-
Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules.Molecules. 2020 Oct 22;25(21):4878. doi: 10.3390/molecules25214878. Molecules. 2020. PMID: 33105694 Free PMC article. Review.
Cited by
-
Green tea extract reduces viral proliferation and ROS production during Feline Herpesvirus type-1 (FHV-1) infection.BMC Vet Res. 2024 Aug 22;20(1):374. doi: 10.1186/s12917-024-04227-0. BMC Vet Res. 2024. PMID: 39175036 Free PMC article.
-
Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses.Adv Exp Med Biol. 2024;1451:337-354. doi: 10.1007/978-3-031-57165-7_22. Adv Exp Med Biol. 2024. PMID: 38801589 Review.
-
Effect of Flavonols of Aronia melanocarpa Fruits on Morphofunctional State of Immunocompetent Organs of Rats under Cyclophosphamide-Induced Immunosuppression.Biomolecules. 2024 May 14;14(5):578. doi: 10.3390/biom14050578. Biomolecules. 2024. PMID: 38785985 Free PMC article.
-
Repurposing of Plant-based Antiviral Molecules for the Treatment of COVID-19.Curr Top Med Chem. 2024;24(7):614-633. doi: 10.2174/0115680266276749240206101847. Curr Top Med Chem. 2024. PMID: 38477206 Review.
-
Organ-on-Chip: Advancing Nutraceutical Testing for Improved Health Outcomes.ACS Omega. 2023 Aug 21;8(35):31632-31647. doi: 10.1021/acsomega.3c03155. eCollection 2023 Sep 5. ACS Omega. 2023. PMID: 37692213 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous