Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Apr;18(4):243-254.
doi: 10.1038/nri.2017.136. Epub 2018 Jan 2.

Peptidoglycan recognition by the innate immune system

Andrea J Wolf  1 , David M Underhill  1   2
Affiliations
Review

Peptidoglycan recognition by the innate immune system

Andrea J Wolf et al. Nat Rev Immunol. 2018 Apr.

Abstract

The innate immune system recognizes microbial products using germline-encoded receptors that initiate inflammatory responses to infection. The bacterial cell wall component peptidoglycan is a prime example of a conserved pathogen-associated molecular pattern (PAMP) for which the innate immune system has evolved sensing mechanisms. Peptidoglycan is a direct target for innate immune receptors and also regulates the accessibility of other PAMPs to additional innate immune receptors. Subtle structural modifications to peptidoglycan can influence the ability of the innate immune system to detect bacteria and can allow bacteria to evade or alter host defences. This Review focuses on the mechanisms of peptidoglycan recognition that are used by mammalian cells and discusses new insights into the role of peptidoglycan recognition in inflammation, metabolism, immune homeostasis and disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Am J Gastroenterol. 2007 Jun;102(6):1259-67 - PubMed
    1. Cell. 2016 Jul 28;166(3):624-636 - PubMed
    1. J Biol Chem. 2003 Mar 14;278(11):8869-72 - PubMed
    1. J Immunol. 2008 Mar 15;180(6):4050-7 - PubMed
    1. Eur J Immunol. 2004 Jul;34(7):2052-9 - PubMed

LinkOut - more resources