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Observational Study
. 2017 Nov 22;50(5):1701162.
doi: 10.1183/13993003.01162-2017. Print 2017 Nov.

Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD

Ciro Casanova  1 , Bartolome R Celli  2 , Juan P de-Torres  3 , Cristina Martínez-Gonzalez  4 , Borja G Cosio  5   6 , Victor Pinto-Plata  7 , Pilar de Lucas-Ramos  8 , Miguel Divo  2 , Antonia Fuster  9 , Germán Peces-Barba  6   10 , Myriam Calle-Rubio  11 , Ingrid Solanes  12 , Ramón Aguero  13 , Nuria Feu-Collado  14 , Inmaculada Alfageme  15 , Alfredo De Diego  16 , Amparo Romero  17 , Eva Balcells  18 , Antonia Llunell  19 , Juan B Galdiz  20 , Margarita Marin  21 , Amalia Moreno  22 , Carlos Cabrera  23 , Rafael Golpe  24 , Celia Lacarcel  25 , Joan B Soriano  26 , José Luis López-Campos  6   27 , Juan J Soler-Cataluña  28 , José M Marin  29
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Free article
Observational Study

Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD

Ciro Casanova et al. Eur Respir J. .
Free article

Abstract

The impact of blood eosinophilia in chronic obstructive pulmonary disease (COPD) remains controversial.To evaluate the prevalence and stability of a high level of blood eosinophils (≥300 cells·μL-1) and its relationship to outcomes, we determined blood eosinophils at baseline and over 2 years in 424 COPD patients (forced expiratory volume in 1 s (FEV1) 60% predicted) and 67 smokers without COPD from the CHAIN cohort, and in 308 COPD patients (FEV1 60% predicted) in the BODE cohort. We related eosinophil levels to exacerbations and survival using Cox hazard analysis.In COPD patients, 15.8% in the CHAIN cohort and 12.3% in the BODE cohort had persistently elevated blood eosinophils at all three visits. A significant proportion (43.8%) of patients had counts that oscillated above and below the cut-off points, while the rest had persistent eosinophil levels <300 cells·μL-1 A similar eosinophil blood pattern was observed in controls. Exacerbation rates did not differ in patients with and without eosinophilia. All-cause mortality was lower in patients with high eosinophils compared with those with values <300 cells·μL-1 (15.8% versus 33.7%; p=0.026).In patients with COPD, blood eosinophils ≥300 cells·μL-1 persisting over 2 years was not a risk factor for COPD exacerbations. High eosinophil count was associated with better survival.

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Conflict of interest statement

Conflict of interest: Disclosures can be found alongside this article at erj.ersjournals.com

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