The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
- PMID: 29113509
- DOI: 10.1080/13813455.2017.1398262
The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
Abstract
Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA).
Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats.
Methods: Male Sprague-Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Blood glucose, metabolic hormones and the white blood cell (WBC) composition were analysed.
Results: IPA (mean intake 27.3 mg/kg/day) significantly lowered fasting blood glucose level by 0.42 mM (95% CI 0.11-0.73). Similarly, fasting plasma insulin levels and the homeostatic model assessment (HOMA) index of insulin resistance were reduced, whereas plasma metabolic hormones, behaviour and WBC composition remained unaffected by IPA.
Conclusions: Our findings highlight IPA as a promising candidate for treatment of metabolic disorders associated with insulin resistance.
Keywords: Blood glucose; depression; diabetes mellitus; insulin; xenobiotics.
Similar articles
-
Angelica sinensis polysaccharide regulates glucose and lipid metabolism disorder in prediabetic and streptozotocin-induced diabetic mice through the elevation of glycogen levels and reduction of inflammatory factors.Food Funct. 2015 Mar;6(3):902-9. doi: 10.1039/c4fo00859f. Food Funct. 2015. PMID: 25630053
-
Diabetes and branched-chain amino acids: What is the link?J Diabetes. 2018 May;10(5):350-352. doi: 10.1111/1753-0407.12645. Epub 2018 Feb 13. J Diabetes. 2018. PMID: 29369529
-
Effects of Obex in Overweight and Obese Subjects With or Without Impaired Fasting Glucose: A Pilot Study.J Diet Suppl. 2017 Nov 2;14(6):626-639. doi: 10.1080/19390211.2017.1304482. Epub 2017 Apr 6. J Diet Suppl. 2017. PMID: 28384000
-
Glucose-induced insulin secretion: nutritional prevention and novel avenues for therapy.Adv Exp Med Biol. 2012;771:319-39. Adv Exp Med Biol. 2012. PMID: 23393688 Review.
-
The Mechanism Underlying the Influence of Indole-3-Propionic Acid: A Relevance to Metabolic Disorders.Front Endocrinol (Lausanne). 2022 Mar 18;13:841703. doi: 10.3389/fendo.2022.841703. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35370963 Free PMC article. Review.
Cited by
-
The Human Microbiome as a Therapeutic Target for Metabolic Diseases.Nutrients. 2024 Jul 19;16(14):2322. doi: 10.3390/nu16142322. Nutrients. 2024. PMID: 39064765 Free PMC article. Review.
-
Harnessing and delivering microbial metabolites as therapeutics via advanced pharmaceutical approaches.Pharmacol Ther. 2024 Apr;256:108605. doi: 10.1016/j.pharmthera.2024.108605. Epub 2024 Feb 16. Pharmacol Ther. 2024. PMID: 38367866 Review.
-
Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.Circ Res. 2024 Feb 16;134(4):371-389. doi: 10.1161/CIRCRESAHA.123.322381. Epub 2024 Jan 24. Circ Res. 2024. PMID: 38264909
-
Impact of gut microbiota and associated mechanisms on postprandial glucose levels in patients with diabetes.J Transl Int Med. 2023 Dec 20;11(4):363-371. doi: 10.2478/jtim-2023-0116. eCollection 2023 Dec. J Transl Int Med. 2023. PMID: 38130636 Free PMC article.
-
Discrete interplay of gut microbiota L-tryptophan metabolites in host biology and disease.Mol Cell Biochem. 2024 Sep;479(9):2273-2290. doi: 10.1007/s11010-023-04867-0. Epub 2023 Oct 20. Mol Cell Biochem. 2024. PMID: 37861881 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
