Review
doi: 10.1007/82_2017_72.
The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir
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- PMID: 29071476
- DOI: 10.1007/82_2017_72
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Review
The Antiviral Immune Response and Its Impact on the HIV-1 Reservoir
Curr Top Microbiol Immunol.
2018.
Abstract
Latently infected resting memory CD4+ T cells represent a major barrier to HIV-1 eradication. Studies have shown that it will not be possible to cure HIV-1 infection unless these cells are eliminated. Latently infected cells probably do not express viral antigens and thus may not be susceptible to the HIV-1 specific immune response, nevertheless the size and composition of the reservoir is influenced by the immune system. In this chapter, we review the different components of the HIV-1 specific immune response and discuss how the immune system can be harnessed to eradicate the virus.
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