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. 2017 May 10;8(42):71556-71562.
doi: 10.18632/oncotarget.17746. eCollection 2017 Sep 22.

A single nucleotide polymorphism of AIRE gene located in the 21q22.3 increases the risk of rheumatoid arthritis

Yuan-Sheng Xu  1 , Xi-Jia Jiang  2 , Jian-Min Chen  1
Affiliations

A single nucleotide polymorphism of AIRE gene located in the 21q22.3 increases the risk of rheumatoid arthritis

Yuan-Sheng Xu et al. Oncotarget. .

Abstract

Several studies addressed the association of autoimmune regulator (AIRE) gene polymorphism with the risk of rheumatoid arthritis (RA); however, their conclusions were inconsistent. For better investigating the effects of this polymorphism on the risk of RA, we conducted this study to evaluate the role of AIRE rs2075786 polymorphism in the risk of RA. Four eligible studies involving 6,755 cases and 7,970 controls were identified by searching the databases of PubMed, CNKI and EMBASE up to February 2017. Our study revealed that AIRE rs2075786 polymorphism was associated with an increased risk of RA under all genetic models. In the subgroup analysis, AIRE rs2075786 polymorphism contributed to RA susceptibility among Asians, but not among Caucasians. To summarize,, this meta-analysis confirms that AIRE rs2075786 polymorphism may play a significant role in increasing the risk of RA. Stratification analysis by ethnicity reveals that AIRE rs2075786 polymorphism is associated with an increased risk of RA among Asians, but not among Caucasians. These findings need further validation in the large multicenter case-control studies.

Keywords: AIRE; rheumatoid arthritis; single nucleotide polymorphism.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Selection for eligible citations included in this meta-analysis
Figure 2
Figure 2. Forest plot shows odds ratio for the association between AIRE gene rs2075786 polymorphism and RA risk (A vs. G)
Figure 3
Figure 3. Stratification analyses of ethnicity shows odds ratio for the association between AIRE gene rs2075786 polymorphism and RA risk (AA+GA vs. GG)
Figure 4
Figure 4. Begg's tests between AIRE gene rs2075786 polymorphism and RA risk (AA vs. GG)
See this image and copyright information in PMC

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