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Review
. 2017 Nov:136 Suppl 201:37-44.
doi: 10.1111/ane.12840.

The clinical utility of JC virus antibody index measurements in the context of progressive multifocal leukoencephalopathy

A Q Reuwer  1 , M Heron  1 , D van der Dussen  2 , T Schneider-Hohendorf  3 , J L Murk  1
Affiliations
Review

The clinical utility of JC virus antibody index measurements in the context of progressive multifocal leukoencephalopathy

A Q Reuwer et al. Acta Neurol Scand. 2017 Nov.

Abstract

In natalizumab-treated patients without previous immunosuppressive treatment, the JCV antibody index is used to stratify PML risk. A high index value indicates that the risk to develop PML is significantly elevated, although probably about 99% of patients with this index value will not develop PML. This minireview aimed to provide an overview of the basic virology and immunology relevant to understanding JCV infections in MS patients, with a focus on what is presently known about antibodies to JCV and how they could be of use to predict and diagnose PML.

Keywords: JC virus; adaptive immune response; antibodies, antibody index; neuro-immune surveillance; progressive multifocal leukoencephalopathy.

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