doi: 10.1016/0742-8413(88)90044-8.
Pyrethroids and the striatal dopaminergic system in vivo
Affiliations
- PMID: 2905952
- DOI: 10.1016/0742-8413(88)90044-8
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Pyrethroids and the striatal dopaminergic system in vivo
Comp Biochem Physiol C Comp Pharmacol Toxicol.
1988.
Abstract
1. Type I (permethrin and allethrin) or type II (cypermethrin and fenvalerate) pyrethroids caused 23-37% increases in the striatal content of the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC). 2. Toxicity symptoms and increases in DOPAC were associated with higher brain concentrations for type I (2.6-5.8 micrograms/gm) than type II pyrethroids (0.4-0.6 micrograms/gm). 3. No specific difference in the interaction between type I and II pyrethroids and the striatal dopaminergic system were recognized.
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