Comment
doi: 10.1016/j.stem.2017.09.012.
Mononuclear Diploidy at the Heart of Cardiomyocyte Proliferation
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- PMID: 28985522
- DOI: 10.1016/j.stem.2017.09.012
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Comment
Mononuclear Diploidy at the Heart of Cardiomyocyte Proliferation
Cell Stem Cell.
.
Free article
Abstract
Reporting in Nature Genetics, Patterson et al. (2017) show that adult mammalian hearts possess an innate capacity to regenerate, which depends on a small population of mononuclear diploid cardiomyocytes. These cells undergo karyokinesis and cytokinesis, raising the possibility that endogenous cardiac muscle cells can be stimulated to proliferate for myocardial repair.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration.Nat Genet. 2017 Sep;49(9):1346-1353. doi: 10.1038/ng.3929. Epub 2017 Aug 7. Nat Genet. 2017. PMID: 28783163 Free PMC article.
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