Designing lipid nanoparticles for topical ocular drug delivery

doi:10.1016/j.ijpharm.2017.09.017

Review

. 2017 Oct 30;532(1):204-217.

doi: 10.1016/j.ijpharm.2017.09.017. Epub 2017 Sep 8.

Designing lipid nanoparticles for topical ocular drug delivery

Jesus Alvarez-Trabado¹, Yolanda Diebold², Alejandro Sanchez³

Affiliations

¹ Institute of Applied Ophthalmo-Biology (IOBA), University of Valladolid, 47011 Valladolid, Spain; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Campus Vida, 15782 Santiago de Compostela, Spain.
² Institute of Applied Ophthalmo-Biology (IOBA), University of Valladolid, 47011 Valladolid, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, Spain.
³ Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Campus Vida, 15782 Santiago de Compostela, Spain; Genetics and Biology of the Development of Kidney Diseases Unit, Sanitary Research Institute (IDIS) of the University Hospital Complex of Santiago de Compostela (CHUS), Travesía da Choupana, s/n, 15706 Santiago de Compostela, Spain. Electronic address: alejandro.sanchez@usc.es.

PMID: 28893582
DOI: 10.1016/j.ijpharm.2017.09.017

Review

Designing lipid nanoparticles for topical ocular drug delivery

Jesus Alvarez-Trabado et al. Int J Pharm. 2017.

. 2017 Oct 30;532(1):204-217.

doi: 10.1016/j.ijpharm.2017.09.017. Epub 2017 Sep 8.

Authors

Jesus Alvarez-Trabado¹, Yolanda Diebold², Alejandro Sanchez³

Affiliations

¹ Institute of Applied Ophthalmo-Biology (IOBA), University of Valladolid, 47011 Valladolid, Spain; Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Campus Vida, 15782 Santiago de Compostela, Spain.
² Institute of Applied Ophthalmo-Biology (IOBA), University of Valladolid, 47011 Valladolid, Spain; Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Valladolid, Spain.
³ Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Santiago de Compostela (USC), Campus Vida, 15782 Santiago de Compostela, Spain; Genetics and Biology of the Development of Kidney Diseases Unit, Sanitary Research Institute (IDIS) of the University Hospital Complex of Santiago de Compostela (CHUS), Travesía da Choupana, s/n, 15706 Santiago de Compostela, Spain. Electronic address: alejandro.sanchez@usc.es.

PMID: 28893582
DOI: 10.1016/j.ijpharm.2017.09.017

Abstract

Topically-applied dosage forms, such eye drops, are the most used formulations in the treatment of ocular diseases. Nonetheless, because of the special protection of the eye associated with the ocular surface, drug bioavailability and subsequent therapeutic efficiency obtained with these conventional dosage forms are very low. Recently, novel drug delivery systems have been proposed to solve the main drawbacks of conventional formulations. Nanotechnology, and more specifically lipid nanoparticles, have emerged as promising "modified eyedrops" with the purpose of improving therapeutic efficiency without compromising drug safety and patient compliance. The purpose of this review is to offer an overview of lipid nanoparticles as feasible alternatives to the conventional topically-applied dosage forms. We discuss the main limitations of topical ocular drug delivery and describe how correctly designed lipid nanoparticles can be highly valuable tools to overcome the constraints imposed by the ocular surface. Special emphasis is placed on the description of production methods and bulk materials used in the development of lipid nanoparticles for ophthalmic use and how both issues will determine the physicochemical and biopharmaceutical properties of the developed nanosystems.

Keywords: Cyclosporine; Drug delivery; Lipid nanoparticles; Ocular; Topical.

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Designing lipid nanoparticles for topical ocular drug delivery

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Designing lipid nanoparticles for topical ocular drug delivery

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