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Review
. 2017 Sep 1;24(1):65.
doi: 10.1186/s12929-017-0372-6.

FTO associations with obesity and telomere length

Yuling Zhou  1 , Brett D Hambly  2 , Craig S McLachlan  3
Affiliations
Review

FTO associations with obesity and telomere length

Yuling Zhou et al. J Biomed Sci. .

Abstract

This review examines the biology of the Fat mass- and obesity-associated gene (FTO), and the implications of genetic association of FTO SNPs with obesity and genetic aging. Notably, we focus on the role of FTO in the regulation of methylation status as possible regulators of weight gain and genetic aging. We present a theoretical review of the FTO gene with a particular emphasis on associations with UCP2, AMPK, RBL2, IRX3, CUX1, mTORC1 and hormones involved in hunger regulation. These associations are important for dietary behavior regulation and cellular nutrient sensing via amino acids. We suggest that these pathways may also influence telomere regulation. Telomere length (TL) attrition may be influenced by obesity-related inflammation and oxidative stress, and FTO gene-involved pathways. There is additional emerging evidence to suggest that telomere length and obesity are bi-directionally associated. However, the role of obesity risk-related genotypes and associations with TL are not well understood. The FTO gene may influence pathways implicated in regulation of TL, which could help to explain some of the non-consistent relationship between weight phenotype and telomere length that is observed in population studies investigating obesity.

Keywords: Energy balance; FTO SNPs; Genetic polymorphism; Nutrient sensing; Obesity; Telomere length.

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The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
FTO gene interacts with telomere length and obesity. FTO interacts with uncoupling protein 2 (UCP2), AMP-activated protein kinase (AMPK), retinoblastoma-like 2 protein (RBL2), Iroquois homeobox protein 3 (IRX3), cut like homeobox 1 (CUX1) and mammalian target of rapamycin complex 1 (mTORC1). These interactions are important for dietary behavior regulation and cellular nutrient sensing. Additionally, the hypothesis is presented that the FTO genotype may influence telomere regulation. Bold arrow means there is published evidence; dotted arrow means there is rational speculation but without published evidence
See this image and copyright information in PMC

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