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. 2017 Dec;137(12):2630-2638.
doi: 10.1016/j.jid.2017.08.003. Epub 2017 Aug 12.

MicroRNA-132 with Therapeutic Potential in Chronic Wounds

Xi Li  1 , Dongqing Li  1 , Aoxue Wang  2 , Tongbin Chu  3 , Warangkana Lohcharoenkal  1 , Xiaowei Zheng  4 , Jacob Grünler  5 , Sampath Narayanan  5 , Sofie Eliasson  5 , Eva K Herter  1 , Yang Wang  2 , Yannan Ma  2 , Marcus Ehrström  6 , Liv Eidsmo  7 , Maria Kasper  8 , Andor Pivarcsi  1 , Enikö Sonkoly  7 , Sergiu-Bogdan Catrina  4 , Mona Ståhle  7 , Ning Xu Landén  9
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Free article

MicroRNA-132 with Therapeutic Potential in Chronic Wounds

Xi Li et al. J Invest Dermatol. 2017 Dec.
Free article

Abstract

Chronic wounds represent a major and rising health and economic burden worldwide. There is a continued search toward more effective wound therapy. We found significantly reduced microRNA-132 (miR-132) expression in human diabetic ulcers compared with normal skin wounds and also in skin wounds of leptin receptor-deficient (db/db) diabetic mice compared with wild-type mice. Local replenishment of miR-132 in the wounds of db/db mice accelerated wound closure effectively, which was accompanied by increased proliferation of wound edge keratinocytes and reduced inflammation. The pro-healing effect of miR-132 was further supported by global transcriptome analysis, which showed that several inflammation-related signaling pathways (e.g., NF-κB, NOD-like receptor, toll-like receptor, and tumor necrosis factor signaling pathways) were the top ones regulated by miR-132 in vivo. Moreover, we topically applied liposome-formulated miR-132 mimics mixed with pluronic F-127 gel on human ex vivo skin wounds, which promoted re-epithelialization. Together, our study showed the therapeutic potential of miR-132 in chronic wounds, which warrants further evaluation in controlled clinical trials.

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