doi: 10.1016/s0140-6736(87)91728-4.
Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease
- PMID: 2880163
- DOI: 10.1016/s0140-6736(87)91728-4
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Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease
Lancet.
.
Abstract
Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0.1 ng/ml recombinant TNF) died.
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