Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms

doi:10.3390/nu9080857

Review

. 2017 Aug 10;9(8):857.

doi: 10.3390/nu9080857.

Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms

Guo-Yi Tang¹, Xiao Meng², Ya Li³, Cai-Ning Zhao⁴, Qing Liu⁵, Hua-Bin Li^{6

7}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. tanggy5@mail2.sysu.edu.cn.
² Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. mengx7@mail2.sysu.edu.cn.
³ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
⁴ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. zhaocn@mail2.sysu.edu.cn.
⁵ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. liuq248@mail2.sysu.edu.cn.
⁶ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
⁷ South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.

PMID: 28796173
PMCID: PMC5579650
DOI: 10.3390/nu9080857

Review

Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms

Guo-Yi Tang et al. Nutrients. 2017.

. 2017 Aug 10;9(8):857.

doi: 10.3390/nu9080857.

Authors

Guo-Yi Tang¹, Xiao Meng², Ya Li³, Cai-Ning Zhao⁴, Qing Liu⁵, Hua-Bin Li^{6

7}

Affiliations

¹ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. tanggy5@mail2.sysu.edu.cn.
² Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. mengx7@mail2.sysu.edu.cn.
³ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. liya28@mail2.sysu.edu.cn.
⁴ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. zhaocn@mail2.sysu.edu.cn.
⁵ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. liuq248@mail2.sysu.edu.cn.
⁶ Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
⁷ South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China. lihuabin@mail.sysu.edu.cn.

PMID: 28796173
PMCID: PMC5579650
DOI: 10.3390/nu9080857

Abstract

Epidemiological studies have shown that vegetable consumption is inversely related to the risk of cardiovascular diseases. Moreover, research has indicated that many vegetables like potatoes, soybeans, sesame, tomatoes, dioscorea, onions, celery, broccoli, lettuce and asparagus showed great potential in preventing and treating cardiovascular diseases, and vitamins, essential elements, dietary fibers, botanic proteins and phytochemicals were bioactive components. The cardioprotective effects of vegetables might involve antioxidation; anti-inflammation; anti-platelet; regulating blood pressure, blood glucose, and lipid profile; attenuating myocardial damage; and modulating relevant enzyme activities, gene expression, and signaling pathways as well as some other biomarkers associated to cardiovascular diseases. In addition, several vegetables and their bioactive components have been proven to protect against cardiovascular diseases in clinical trials. In this review, we analyze and summarize the effects of vegetables on cardiovascular diseases based on epidemiological studies, experimental research, and clinical trials, which are significant to the application of vegetables in prevention and treatment of cardiovascular diseases.

Keywords: bioactive component; cardiovascular disease; effect; mechanism; vegetable.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
The cardioprotective effects of vegetables.

See this image and copyright information in PMC

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References

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[1] Liu M.B., Wang W., Zhou M.G. Trend analysis on the mortality of cardiovascular diseases from 2004 to 2010 in China. Chin. J. Epidemiol. 2013;34:985–988. - PubMed

[2] Liu M.B., Wang W., Zhou M.G. Trend analysis on the mortality of cardiovascular diseases from 2004 to 2010 in China. Chin. J. Epidemiol. 2013;34:985–988. - PubMed

[3] Celermajer D.S., Chow C.K., Marijon E., Anstey N.M., Woo K.S. Cardiovascular disease in the developing world: Prevalences, patterns, and the potential of early disease detection. J. Am. Coll. Cardiol. 2012;60:1207–1216. doi: 10.1016/j.jacc.2012.03.074. - DOI - PubMed

[4] Celermajer D.S., Chow C.K., Marijon E., Anstey N.M., Woo K.S. Cardiovascular disease in the developing world: Prevalences, patterns, and the potential of early disease detection. J. Am. Coll. Cardiol. 2012;60:1207–1216. doi: 10.1016/j.jacc.2012.03.074. - DOI - PubMed

[5] WHO Cardiovascular Diseases (CVDs) [(accessed on 13 March 2017)]; Available online: http://www.who.int/cardiovascular_diseases/en/

[6] WHO Cardiovascular Diseases (CVDs) [(accessed on 13 March 2017)]; Available online: http://www.who.int/cardiovascular_diseases/en/

[7] Yazdanyar A., Newman A.B. The burden of cardiovascular disease in the elderly: Morbidity, mortality, and costs. Clin. Geriatr. Med. 2009;25:563–577. doi: 10.1016/j.cger.2009.07.007. - DOI - PMC - PubMed

[8] Yazdanyar A., Newman A.B. The burden of cardiovascular disease in the elderly: Morbidity, mortality, and costs. Clin. Geriatr. Med. 2009;25:563–577. doi: 10.1016/j.cger.2009.07.007. - DOI - PMC - PubMed

[9] Zaina S., Lund G. Epigenetics: A tool to understand diet-related cardiovascular risk? J. Nutrigenet. Nutrigenom. 2011;4:261–274. doi: 10.1159/000334584. - DOI - PubMed

[10] Zaina S., Lund G. Epigenetics: A tool to understand diet-related cardiovascular risk? J. Nutrigenet. Nutrigenom. 2011;4:261–274. doi: 10.1159/000334584. - DOI - PubMed

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Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms

Affiliations

Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms

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