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. 2017 Dec;53(6):918-921.
doi: 10.1007/s11262-017-1500-9. Epub 2017 Aug 9.

Whole-genome sequence analysis of Zika virus, amplified from urine of traveler from the Philippines

Se Hun Gu  1 , Dong Hyun Song  1 , Daesang Lee  1 , Jeyoun Jang  2 , Min Young Kim  2 , Jaehun Jung  3 , Koung In Woo  3 , Mirang Kim  3 , Woong Seog  3 , Hong Sang Oh  3 , Byung Seop Choi  3 , Jong-Seong Ahn  3 , Quehn Park  2 , Seong Tae Jeong  4
Affiliations

Whole-genome sequence analysis of Zika virus, amplified from urine of traveler from the Philippines

Se Hun Gu et al. Virus Genes. 2017 Dec.

Abstract

Zika virus (ZIKV) (genus Flavivirus, family Flaviviridae) is an emerging pathogen associated with microcephaly and Guillain-Barré syndrome. The rapid spread of ZIKV disease in over 60 countries and the large numbers of travel-associated cases have caused worldwide concern. Thus, intensified surveillance of cases among immigrants and tourists from ZIKV-endemic areas is important for disease control and prevention. In this study, using Next Generation Sequencing, we reported the first whole-genome sequence of ZIKV strain AFMC-U, amplified from the urine of a traveler returning to Korea from the Philippines. Phylogenetic analysis showed geographic-specific clustering. Our results underscore the importance of examining urine in the diagnosis of ZIKV infection.

Keywords: Next generation sequencing (NGS); Philippines; South Korea; Whole-genome sequence; Zika virus.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures involving human participant was in accordance with ethical standards.

Figures

Fig. 1
Fig. 1
Phylogenetic analysis of the complete-genome sequences of Zika virus for a travel-associated case of Zika virus infection in a traveler returning to Korea from Boracay, Philippines, in April 2016. Phylogenetic tree was generated by the neighbor-joining method, using the Kimura 2-parameter model. Scale bar indicates number of base substitutions per site
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