Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Sep;17(9):59.
doi: 10.1007/s11882-017-0726-x.

Therapy of Sinonasal Microbiome in CRS: A Critical Approach

Alkis J Psaltis  1 , Peter-John Wormald  2
Affiliations
Review

Therapy of Sinonasal Microbiome in CRS: A Critical Approach

Alkis J Psaltis et al. Curr Allergy Asthma Rep. 2017 Sep.

Abstract

Purpose of review: Perturbations in local microbiota have been demonstrated in many chronic inflammatory diseases including chronic rhinosinusitis (CRS). The purpose of this paper is to review the latest microbiome research as it pertains to CRS and establish whether there is any evidence supporting the microbiome hypothesis for CRS. Treatment factors that may influence the sinonasal microbiome as well as the role of probiotics are also discussed.

Recent findings: Despite significant heterogeneity in study design, tissue sampling, processing and bioinformatics analysis, consistent findings have emerged from the recent literature. Healthy individuals and CRS patients have similar overall bacterial burden of disease and share many common phylum. CRS patients, however, routinely show reductions in markers of biodiversity. Both medical and surgical treatments appear to influence the sinonasal microbiome, with certain bacterial strains associated with better treatment outcomes. The presence of microbial dysbiosis in CRS is now supported by numerous studies. Whether this dysbiosis is a cause or rather an association of the disease process still remains unclear. Although probiotic therapies show early promise, much larger studies are required to establish their real role as a treatment for CRS.

Keywords: Chronic rhinosinusitis; Microbial dysbiosis; Microbiota; Sinonasal microbiome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Int Forum Allergy Rhinol. 2016 Jan;6(1):34-40 - PubMed
    1. Otolaryngol Head Neck Surg. 2009 Feb;140(2):202-8 - PubMed
    1. Arzneimittelforschung. 2002;52(8):622-7 - PubMed
    1. Am J Rhinol Allergy. 2016 May;30(3):161-6 - PubMed
    1. Trends Endocrinol Metab. 2016 Dec;27(12 ):831-843 - PubMed

LinkOut - more resources