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Review
. 2017 Jul 26:9:59.
doi: 10.1186/s13098-017-0254-9. eCollection 2017.

Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications

Ramesh C Gupta  1   2 , Dennis Chang  1   3 , Srinivas Nammi  1   3 , Alan Bensoussan  1 , Kellie Bilinski  1 , Basil D Roufogalis  1   4
Affiliations
Review

Interactions between antidiabetic drugs and herbs: an overview of mechanisms of action and clinical implications

Ramesh C Gupta et al. Diabetol Metab Syndr. .

Abstract

Diabetes is a complex condition with a variety of causes and pathophysiologies. The current single target approach has not provided ideal clinical outcomes for the treatment of the disease and its complications. Herbal medicine has been used for the management of various diseases such as diabetes over centuries. Many diabetic patients are known to use herbal medicines with antidiabetic properties in addition to their mainstream treatments, which may present both a benefit as well as potential risk to effective management of their disease. In this review we evaluate the clinical and experimental literature on herb-drug interactions in the treatment of diabetes. Pharmacokinetic and pharmacodynamic interactions between drugs and herbs are discussed, and some commonly used herbs which can interact with antidiabetic drugs summarised. Herb-drug interactions can be a double-edged sword presenting both risks (adverse drug events) and benefits (through enhancement). There is a general lack of data on herb-drug interactions. As such, more rigorous scientific research is urgently needed to guide clinical practice as well as to safeguard the wellbeing of diabetes patients.

Keywords: Antidiabetic drugs; Antidiabetic herbs; Herb–drug interactions; Pharmacodynamics interaction; Pharmacokinetic interaction; Synergism.

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Fig. 1
Fig. 1
Mechanisms of action of herb–drug interactions
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