Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

doi:10.1155/2017/1653254

Review

. 2017:2017:1653254.

doi: 10.1155/2017/1653254. Epub 2017 Jul 5.

Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

Beata Kocan^{1

2}, Aleksandra Maziarz^{1

2}, Jacek Tabarkiewicz^{1

2}, Takahiro Ochiya³, Agnieszka Banaś-Ząbczyk^{1

2}

Affiliations

¹ Laboratory of Stem Cells' Biology, Department of Human Immunology, Chair of Preclinical Studies, Institute of Experimental and Clinical Medicine, Faculty of Medicine, University of Rzeszow, Ul. Kopisto 2a, 35-310 Rzeszow, Poland.
² Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Ul. Warzywna 1a, 35-310 Rzeszow, Poland.
³ Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

PMID: 28757877
PMCID: PMC5516761
DOI: 10.1155/2017/1653254

Review

Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

Beata Kocan et al. Stem Cells Int. 2017.

. 2017:2017:1653254.

doi: 10.1155/2017/1653254. Epub 2017 Jul 5.

Authors

Beata Kocan^{1

2}, Aleksandra Maziarz^{1

2}, Jacek Tabarkiewicz^{1

2}, Takahiro Ochiya³, Agnieszka Banaś-Ząbczyk^{1

2}

Affiliations

¹ Laboratory of Stem Cells' Biology, Department of Human Immunology, Chair of Preclinical Studies, Institute of Experimental and Clinical Medicine, Faculty of Medicine, University of Rzeszow, Ul. Kopisto 2a, 35-310 Rzeszow, Poland.
² Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Ul. Warzywna 1a, 35-310 Rzeszow, Poland.
³ Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, Tokyo 104-0045, Japan.

PMID: 28757877
PMCID: PMC5516761
DOI: 10.1155/2017/1653254

Abstract

There has been an increased interest in mesenchymal stem cells from adipose tissue, due to their abundance and accessibility with no ethical concerns. Their multipotent properties make them appropriate for regenerative clinical applications. It has been shown that adipose-derived stem cells (ASCs) may differ between the origin sites. Moreover, a variety of internal and external factors may affect their biological characteristics, as what we aimed to highlight in this review. It has been demonstrated that ASCs secrete multiple trophic factors that are capable of stimulating cell proliferation and differentiation and migration of various cell types. Particular attention should be given to exosomes, since it is known that they contribute to the paracrine effects of MSCs. Secretion of trophic agents by ASCs is thought to be in a greater importance for regenerative medicine applications, rather than cells engraftment to the site of injury and their differentiation ability. The surface marker profile of ASCs seems to be similar to that of the mesenchymal stem cells from bone marrow, although some molecular differences are observed. Thus, in this review, we have attempted to define trophic activity, as well as phenotypic characterization of ASCs, as crucial factors for therapeutic usage.

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Figures

**Figure 1**
Distribution of brown (BAT) and white (WAT) adipose tissues within the human adult body [, –25].

**Figure 2**
A variety of factors influencing adipose tissue-derived mesenchymal stem cell properties (proliferation capacity, differentiation potential, and trophic effects) [, , , , –, –55].

**Figure 3**
Different types of trophic factors released by adipose tissue-derived mesenchymal stem cells [, –69, 76, 99].

**Figure 4**
Comparison of surface marker profile of mesenchymal stem cells from two distinct origins, bone marrow (BM-MSCs) and adipose tissue (ASCs) [–, , –98].

See this image and copyright information in PMC

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References

1. Barry F. P., Murphy J. M. Mesenchymal stem cells: clinical applications and biological characterization. The International Journal of Biochemistry & Cell Biology. 2004;36(4):568–584. doi: 10.1016/j.biocel.2003.11.001. - DOI - PubMed
1. Zuk P. A., Zhu M., Ashjian P., et al. Human adipose tissue is a source of multipotent stem cells. Molecular Biology of the Cell. 2002;13(12):4279–4295. - PMC - PubMed
1. Bunnell B. A., Flaat M., Gagliardi C., Patel B., Ripoll C. Adipose-derived stem cells: isolation, expansion and differentiation. Methods. 2008;45(2):115–120. doi: 10.1016/j.ymeth.2008.03.006. - DOI - PMC - PubMed
1. Thomson J. A., Itskovitz J., Shapiro S. S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147. doi: 10.1126/science.282.5391.1145. - DOI - PubMed
1. In’t Anker P. S., Scherjon S. A., Kleijburg-van der Keur C., et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells. 2004;22(7):1338–1345. - PubMed

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[1] Barry F. P., Murphy J. M. Mesenchymal stem cells: clinical applications and biological characterization. The International Journal of Biochemistry & Cell Biology. 2004;36(4):568–584. doi: 10.1016/j.biocel.2003.11.001. - DOI - PubMed

[2] Barry F. P., Murphy J. M. Mesenchymal stem cells: clinical applications and biological characterization. The International Journal of Biochemistry & Cell Biology. 2004;36(4):568–584. doi: 10.1016/j.biocel.2003.11.001. - DOI - PubMed

[3] Zuk P. A., Zhu M., Ashjian P., et al. Human adipose tissue is a source of multipotent stem cells. Molecular Biology of the Cell. 2002;13(12):4279–4295. - PMC - PubMed

[4] Zuk P. A., Zhu M., Ashjian P., et al. Human adipose tissue is a source of multipotent stem cells. Molecular Biology of the Cell. 2002;13(12):4279–4295. - PMC - PubMed

[5] Bunnell B. A., Flaat M., Gagliardi C., Patel B., Ripoll C. Adipose-derived stem cells: isolation, expansion and differentiation. Methods. 2008;45(2):115–120. doi: 10.1016/j.ymeth.2008.03.006. - DOI - PMC - PubMed

[6] Bunnell B. A., Flaat M., Gagliardi C., Patel B., Ripoll C. Adipose-derived stem cells: isolation, expansion and differentiation. Methods. 2008;45(2):115–120. doi: 10.1016/j.ymeth.2008.03.006. - DOI - PMC - PubMed

[7] Thomson J. A., Itskovitz J., Shapiro S. S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147. doi: 10.1126/science.282.5391.1145. - DOI - PubMed

[8] Thomson J. A., Itskovitz J., Shapiro S. S., et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145–1147. doi: 10.1126/science.282.5391.1145. - DOI - PubMed

[9] In’t Anker P. S., Scherjon S. A., Kleijburg-van der Keur C., et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells. 2004;22(7):1338–1345. - PubMed

[10] In’t Anker P. S., Scherjon S. A., Kleijburg-van der Keur C., et al. Isolation of mesenchymal stem cells of fetal or maternal origin from human placenta. Stem Cells. 2004;22(7):1338–1345. - PubMed

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Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

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Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential

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