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. 2017 Jul 24;15(7):234.
doi: 10.3390/md15070234.

Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats

Chen-Yuan Chiu  1   2 , Shih-An Feng  3 , Shing-Hwa Liu  4   5   6 , Meng-Tsan Chiang  7
Affiliations

Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats

Chen-Yuan Chiu et al. Mar Drugs. .

Abstract

The present study investigated and compared the regulatory effects on the lipid-related metabolism and intestinal disaccharidase/fecal bacterial enzyme activities between low molecular weight chitosan and chitosan oligosaccharide in high-fat-diet-fed rats. Diet supplementation of low molecular weight chitosan showed greater efficiency than chitosan oligosaccharide in suppressing the increased weights in body and in liver and adipose tissues of high-fat-diet-fed rats. Supplementation of low molecular weight chitosan also showed a greater improvement than chitosan oligosaccharide in imbalance of plasma, hepatic, and fecal lipid profiles, and intestinal disaccharidase activities in high-fat-diet-fed rats. Moreover, both low molecular weight chitosan and chitosan oligosaccharide significantly decreased the fecal microflora mucinase and β-glucuronidase activities in high-fat-diet-fed rats. These results suggest that low molecular weight chitosan exerts a greater positive improvement than chitosan oligosaccharide in lipid metabolism and intestinal disaccharidase activity in high-fat-diet-induced obese rats.

Keywords: chitosan oligosaccharide; fecal mucinase; fecal β-glucuronidase; lipid metabolism; low molecular weight chitosan.

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Conflict of interest statement

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Scheme representing the functional comparison for lipid metabolism and intestinal/fecal enzyme activities between low molecular weight chitosan (LC) and chitosan oligosaccharide (CO) in high-fat (HF)-diet-fed rats. There are the different anti-obesity effects between 5% LC and 5% CO supplementations in HF-diet-fed rats for 10 weeks. LC has relatively greater ability than CO to positively regulate lipid metabolism and intestinal disaccharidase activities in HF-diet-induced obese rats.
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