Cardiomyocyte proliferation: remove brakes and push accelerators

doi:10.1038/cr.2017.91

Review

. 2017 Aug;27(8):959-960.

doi: 10.1038/cr.2017.91. Epub 2017 Jul 14.

Cardiomyocyte proliferation: remove brakes and push accelerators

Lingjuan He¹, Bin Zhou^{1

2}

Affiliations

¹ The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
² School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

PMID: 28707671
PMCID: PMC5539355
DOI: 10.1038/cr.2017.91

Review

Cardiomyocyte proliferation: remove brakes and push accelerators

Lingjuan He et al. Cell Res. 2017 Aug.

. 2017 Aug;27(8):959-960.

doi: 10.1038/cr.2017.91. Epub 2017 Jul 14.

Authors

Lingjuan He¹, Bin Zhou^{1

2}

Affiliations

¹ The State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
² School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.

PMID: 28707671
PMCID: PMC5539355
DOI: 10.1038/cr.2017.91

Abstract

Adult mammalian hearts cannot repair by themselves after injury due to limited proliferation of cardiomyocytes; removal of cell cycle blocker and/or addition of drugs that boost proliferation of cardiomyocytes provide potential means to cardiac regeneration. Three publications that appeared recently in Nature and Cell Research now provide new hope to the treatment of heart injuries.

PubMed Disclaimer

Figures

**Figure 1**
Signaling pathways governing cardiomyocyte proliferation. Left: YAP phosphorylated by Hippo signaling is sequestered by DGC. Myofiber is mature with intact sarcomeric structure. PPARδ/PDK1/AKT/GSK3β/β-cat activity is maintained at basal level. Right: ECM protein agrin binds DGC, which promotes the disassembly of DGC and subsequently myofiber disassembly and YAP activation^,. Chemical compound carbacyclin increases PPARδ activity, which activates β-cat via PDK1/AKT/GSK3β pathway. YAP-TEAD and β-cat-TCF promote transcriptional regulation of cardiomyocyte proliferation.

See this image and copyright information in PMC

Cited by

Direct cardiac reprogramming: A new technology for cardiac repair.
Brlecic PE, Bonham CA, Rosengart TK, Mathison M. Brlecic PE, et al. J Mol Cell Cardiol. 2023 May;178:51-58. doi: 10.1016/j.yjmcc.2023.03.008. Epub 2023 Mar 23. J Mol Cell Cardiol. 2023. PMID: 36965701 Free PMC article. Review.
Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations.
Broughton KM, Sussman MA. Broughton KM, et al. Trends Endocrinol Metab. 2019 Aug;30(8):557-567. doi: 10.1016/j.tem.2019.05.006. Epub 2019 Jun 28. Trends Endocrinol Metab. 2019. PMID: 31262545 Free PMC article. Review.
Molecular mechanisms of exercise contributing to tissue regeneration.
Chen J, Zhou R, Feng Y, Cheng L. Chen J, et al. Signal Transduct Target Ther. 2022 Nov 30;7(1):383. doi: 10.1038/s41392-022-01233-2. Signal Transduct Target Ther. 2022. PMID: 36446784 Free PMC article. Review.
Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI).
Alvarez R Jr, Wang BJ, Quijada PJ, Avitabile D, Ho T, Shaitrit M, Chavarria M, Firouzi F, Ebeid D, Monsanto MM, Navarrete N, Moshref M, Siddiqi S, Broughton KM, Bailey BA, Gude NA, Sussman MA. Alvarez R Jr, et al. J Mol Cell Cardiol. 2019 Feb;127:154-164. doi: 10.1016/j.yjmcc.2018.12.007. Epub 2018 Dec 18. J Mol Cell Cardiol. 2019. PMID: 30571978 Free PMC article.
Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatments.
Basara G, Bahcecioglu G, Ozcebe SG, Ellis BW, Ronan G, Zorlutuna P. Basara G, et al. Biophys Rev (Melville). 2022 Sep;3(3):031305. doi: 10.1063/5.0093399. Epub 2022 Aug 30. Biophys Rev (Melville). 2022. PMID: 36091931 Free PMC article. Review.

See all "Cited by" articles

References

1. Tzahor E, Poss KD. Science 2017; 356:1035–1039. - PMC - PubMed
1. Ellison GM, Vicinanza C, Smith AJ, et al. Cell 2013; 154:827–842. - PubMed
1. van Berlo JH, Kanisicak O, Maillet M, et al. Nature 2014; 509:337–341. - PMC - PubMed
1. Liu Q, Yang R, Huang X, et al. Cell Res 2016; 26:119–130. - PMC - PubMed
1. Bergmann O, Bhardwaj RD, Bernard S, et al. Science 2009; 324:98–102. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Tzahor E, Poss KD. Science 2017; 356:1035–1039. - PMC - PubMed

[2] Tzahor E, Poss KD. Science 2017; 356:1035–1039. - PMC - PubMed

[3] Ellison GM, Vicinanza C, Smith AJ, et al. Cell 2013; 154:827–842. - PubMed

[4] Ellison GM, Vicinanza C, Smith AJ, et al. Cell 2013; 154:827–842. - PubMed

[5] van Berlo JH, Kanisicak O, Maillet M, et al. Nature 2014; 509:337–341. - PMC - PubMed

[6] van Berlo JH, Kanisicak O, Maillet M, et al. Nature 2014; 509:337–341. - PMC - PubMed

[7] Liu Q, Yang R, Huang X, et al. Cell Res 2016; 26:119–130. - PMC - PubMed

[8] Liu Q, Yang R, Huang X, et al. Cell Res 2016; 26:119–130. - PMC - PubMed

[9] Bergmann O, Bhardwaj RD, Bernard S, et al. Science 2009; 324:98–102. - PMC - PubMed

[10] Bergmann O, Bhardwaj RD, Bernard S, et al. Science 2009; 324:98–102. - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cardiomyocyte proliferation: remove brakes and push accelerators

Affiliations

Cardiomyocyte proliferation: remove brakes and push accelerators

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources