Cellular and molecular mechanisms of asthma and COPD
- PMID: 28659395
- DOI: 10.1042/CS20160487
Cellular and molecular mechanisms of asthma and COPD
Abstract
Asthma and chronic obstructive pulmonary disease (COPD) both cause airway obstruction and are associated with chronic inflammation of the airways. However, the nature and sites of the inflammation differ between these diseases, resulting in different pathology, clinical manifestations and response to therapy. In this review, the inflammatory and cellular mechanisms of asthma and COPD are compared and the differences in inflammatory cells and profile of inflammatory mediators are highlighted. These differences account for the differences in clinical manifestations of asthma and COPD and their response to therapy. Although asthma and COPD are usually distinct, there are some patients who show an overlap of features, which may be explained by the coincidence of two common diseases or distinct phenotypes of each disease. It is important to better understand the underlying cellular and molecular mechanisms of asthma and COPD in order to develop new treatments in areas of unmet need, such as severe asthma, curative therapy for asthma and effective anti-inflammatory treatments for COPD.
Keywords: cytokines/2; inflammation; inflammatory cells.
© 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
Similar articles
-
The role of the NLRP3 inflammasome in the pathogenesis of airway disease.Pharmacol Ther. 2011 Jun;130(3):364-70. doi: 10.1016/j.pharmthera.2011.03.007. Epub 2011 Mar 21. Pharmacol Ther. 2011. PMID: 21421008 Review.
-
Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma.J Allergy Clin Immunol. 2003 Nov;112(5):819-27; quiz 828. doi: 10.1016/S0091. J Allergy Clin Immunol. 2003. PMID: 14610463 Review.
-
Airway inflammation and cellular stress in noneosinophilic atopic asthma.Chest. 2006 May;129(5):1194-202. doi: 10.1378/chest.129.5.1194. Chest. 2006. PMID: 16685009
-
Remodeling in asthma and COPD--differences and similarities.Clin Respir J. 2010 May;4 Suppl 1:20-7. doi: 10.1111/j.1752-699X.2010.00193.x. Clin Respir J. 2010. PMID: 20500606 Review.
-
Comparison of cellular and biochemical markers of airway inflammation in patients with mild-to-moderate asthma and chronic obstructive pulmonary disease: an induced sputum and bronchoalveolar lavage fluid study.J Physiol Pharmacol. 2008 Dec;59 Suppl 6:271-83. J Physiol Pharmacol. 2008. PMID: 19218651
Cited by
-
Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling.Front Immunol. 2024 Jan 29;15:1325090. doi: 10.3389/fimmu.2024.1325090. eCollection 2024. Front Immunol. 2024. PMID: 38348034 Free PMC article.
-
Revealing the Mechanisms of Qilongtian Capsules in the Treatment of Chronic Obstructive Pulmonary Disease Based on Integrated Network Pharmacology, Molecular Docking, and In Vivo Experiments.ACS Omega. 2024 Jul 18;9(30):32455-32468. doi: 10.1021/acsomega.3c10163. eCollection 2024 Jul 30. ACS Omega. 2024. PMID: 39100362 Free PMC article.
-
Inhibiting SIRT-2 by AK-7 restrains airway inflammation and oxidative damage promoting lung resurgence through NF-kB and MAP kinase signaling pathway.Front Immunol. 2024 Jun 24;15:1404122. doi: 10.3389/fimmu.2024.1404122. eCollection 2024. Front Immunol. 2024. PMID: 38979411 Free PMC article.
-
Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis.Int J Mol Sci. 2022 Dec 25;24(1):340. doi: 10.3390/ijms24010340. Int J Mol Sci. 2022. PMID: 36613784 Free PMC article. Review.
-
The Use of Video Instructions in Patient Education Promoting Correct Technique for Dry Powder Inhalers: An Investigation on Inhaler-Naïve Individuals.Pharmacy (Basel). 2018 Sep 29;6(4):106. doi: 10.3390/pharmacy6040106. Pharmacy (Basel). 2018. PMID: 30274303 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
