Novel Structural Insights into GPCR-β-Arrestin Interaction and Signaling
- PMID: 28651823
- DOI: 10.1016/j.tcb.2017.05.008
Novel Structural Insights into GPCR-β-Arrestin Interaction and Signaling
Abstract
G protein-coupled receptors (GPCRs) are major signal recognition and transmission units in the plasma membrane. The interaction of activated and phosphorylated GPCRs with the multifunctional adaptor proteins β-arrestins (βarrs) is crucial for regulation of their signaling and functional outcomes. Over the past few years, a range of structural, biochemical, and cellular studies have revealed novel insights into GPCR-βarr interaction and signaling. Some of these findings have come as a surprise and therefore have the potential to significantly refine the conceptual framework of the GPCR-βarr system. Here we discuss these recent advances with particular emphasis on biphasic GPCR-βarr interaction, the formation of GPCR-G-protein-βarr supercomplexes, and receptor-specific conformational signatures in βarrs. We also underline the emerging research areas that are likely to be at the center stage of investigations in the coming years.
Keywords: GPCRs; biased agonism; cellular signaling; desensitization; endocytosis; β-arrestins.
Copyright © 2017 Elsevier Ltd. All rights reserved.
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